Ren Luping, Zhang Junhao, Nie Lei, Shavandi Armin, Yunusov Khaydar E, Aharodnikau Uladzislau E, Solomevich Sergey O, Sun Yanfang, Jiang Guohua
School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, China.
International Scientific and Technological Cooperation Base of Intelligent Biomaterials and Functional Fibers of Zhejiang Province, Hangzhou, 310018, China.
ACS Biomater Sci Eng. 2024 Dec 9;10(12):7492-7506. doi: 10.1021/acsbiomaterials.4c01362. Epub 2024 Nov 4.
Breast cancer (BC) is the most frequently diagnosed cancer in women worldwide. Chemodynamic therapy (CDT), photothermal therapy (PTT), and ion interference therapy (IIT), used in combination, represent a common treatment. In this study, platelet membrane-camouflaged copper-doped CaO biomimetic nanomedicines have been developed for breast cancer treatments. Copper-doped CaO nanoparticles were first coated by polydopamine (PDA) and subsequently camouflaged by platelet membrane (PM) to form platelet membrane-camouflaged copper doped CaO biomimetic nanomedicines (Cu-CaO@PDA/PM). The as-fabricated Cu-CaO@PDA/PM multifunctional nanomedicines could decompose within the tumor microenvironment to release Ca for ion interference therapy, and the generated HO could perform a Fenton-like reaction with the assistance of loaded copper ions to produce ·OH, thus realizing chemodynamic therapy. In addition, the copper ions could also consume glutathione and weaken its ability to scavenge reactive oxygen species, which was conducive to amplifying the effect of oxidative stress. The coating of the polydopamine layer could achieve local hyperthermia of the tumor site, and the surface modification of the platelet membrane could enhance the targeting and biocompatibility of nanomedicines. and tests demonstrated that the developed Cu-CaO@PDA/PM biomimetic nanomedicines offer a promising biomimetic nanoplatform for efficient multimodal combination therapy for breast cancer.
乳腺癌（BC）是全球女性中最常被诊断出的癌症。化学动力疗法（CDT）、光热疗法（PTT）和离子干扰疗法（IIT）联合使用是一种常见的治疗方法。在本研究中，已开发出用于乳腺癌治疗的血小板膜伪装的铜掺杂CaO仿生纳米药物。铜掺杂的CaO纳米颗粒首先用聚多巴胺（PDA）包覆，随后用血小板膜（PM）伪装，以形成血小板膜伪装的铜掺杂CaO仿生纳米药物（Cu-CaO@PDA/PM）。所制备的Cu-CaO@PDA/PM多功能纳米药物可在肿瘤微环境中分解以释放Ca用于离子干扰疗法，并且所产生的H₂O₂可在负载的铜离子的协助下进行类Fenton反应以产生·OH，从而实现化学动力疗法。此外，铜离子还可消耗谷胱甘肽并削弱其清除活性氧的能力，这有利于放大氧化应激的效果。聚多巴胺层的包覆可实现肿瘤部位的局部热疗，而血小板膜的表面修饰可增强纳米药物的靶向性和生物相容性。 和 测试表明，所开发的Cu-CaO@PDA/PM仿生纳米药物为乳腺癌的高效多模态联合治疗提供了一个有前景的仿生纳米平台。
