Zhang Junhao, Chen Nan, Ren Luping, Nie Lei, Yunusov Khaydar E, Aharodnikau Uladzislau E, Solomevich Sergey O, Sun Yanfang, Jiang Guohua
School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China; International Scientific and Technological Cooperation Base of Intelligent Biomaterials and Functional Fibers of Zhejiang Province, Hangzhou 310018, China.
School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Colloids Surf B Biointerfaces. 2025 Jan;245:114293. doi: 10.1016/j.colsurfb.2024.114293. Epub 2024 Oct 4.
In this study, a multifunctional Cu-doped CaO nanoreactor loaded with GOx and camouflaged with a folic acid-modified cell membranewas developed for breast cancer treatment. The as-developed composite nanoreactor showed a synergistic effect on calcium overload to damage mitochondria, thus killing tumor cells to achieve ion interference therapy (IIT). The loaded GOx could deplete glucose to "starve" tumor cells. The HO released by CaO decomposition and enzyme catalytic reactions from GOx could not only be highly toxic in the tumor microenvironment but also enhance the efficiency of chemodynamic therapy (CDT) with Cu. The red blood cell membranes modified by folic acid achieved a combination of active targeting and passive targeting, thereby enhancing the targeting ability of the as-prepared multifunctional composite nanoreactor and prolonging its retention time at the tumor sites for more than 48 h.
在本研究中，开发了一种负载葡萄糖氧化酶（GOx）并用叶酸修饰的细胞膜伪装的多功能铜掺杂氧化钙纳米反应器，用于乳腺癌治疗。所制备的复合纳米反应器对钙超载损伤线粒体具有协同作用，从而杀死肿瘤细胞以实现离子干扰疗法（IIT）。负载的GOx可以消耗葡萄糖来“饿死”肿瘤细胞。氧化钙分解和GOx酶催化反应释放的羟基自由基（HO）不仅在肿瘤微环境中具有高毒性，而且还能提高铜介导的化学动力学疗法（CDT）的效率。叶酸修饰的红细胞膜实现了主动靶向和被动靶向的结合，从而增强了所制备的多功能复合纳米反应器的靶向能力，并将其在肿瘤部位的保留时间延长至48小时以上。
