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腰椎间盘突出症手术中术前腰痛严重程度与术后结果的相关性:一项回顾性队列研究。

Correlation between severity of preoperative low back pain and postoperative outcomes in lumbar disc herniation surgery: a retrospective cohort study.

作者信息

Nakajima Koji, Miyahara Junya, Nakamoto Hideki, Kato So, Taniguchi Yuki, Matsubayashi Yoshitaka, Kawamura Naohiro, Higashikawa Akiro, Takeshita Yujiro, Fukushima Masayoshi, Ono Takashi, Hara Nobuhiro, Okamoto Naoki, Tanaka Sakae, Oshima Yasushi

机构信息

Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan; University of Tokyo Spine Group (UTSG), 7-3-1, Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.

Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan; University of Tokyo Spine Group (UTSG), 7-3-1, Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan; Department of Spine Surgery, The Center Hospital of the National Center for Global Health and Medicine, 1-21-1, Toyama, Shinjuku-Ku, Tokyo, 162-8655, Japan.

出版信息

Spine J. 2025 Mar;25(3):474-484. doi: 10.1016/j.spinee.2024.10.022. Epub 2024 Nov 2.

Abstract

BACKGROUND CONTEXT

Low back pain (LBP) frequently occurs in patients with lumbar disc herniation (LDH), however the extent to which discectomy ameliorates it and how preoperative LBP influences postoperative outcomes remains unclear.

PURPOSE

To evaluate the improvement in LBP and its impact on postoperative patient-reported outcome measures (PROMs).

STUDY DESIGN/SETTING: Multicenter retrospective observational study.

PATIENT SAMPLE

Patients undergoing discectomy for LDH at 8 hospitals from April 2017 to March 2021.

OUTCOME MEASURES

Data were collected on patients' backgrounds, operative factors, and PROMs, including the Numeric Rating Scale (NRS) for pain in the low back, buttock, or leg, EuroQol 5 Dimension (EQ-5D), Oswestry Disability Index (ODI) scores, and postoperative satisfaction.

METHODS

Patients were categorized into mild (NRS 0-3), moderate (NRS 4-7), or severe (NRS 8-10) LBP groups. Inverse probability weighting with propensity scores was used to adjust for demographic and clinical differences between groups. Chi-square tests and one-way analysis of variance were conducted to compare background data and clinical characteristics. Additionally, multivariate logistic regression was performed to identify risk factors for less than 50% improvement in LBP.

RESULTS

This study included 928 patients: 270 mild, 343 moderate, and 315 severe. After adjustment, preoperative NRS scores were significantly different across groups, with scores of 1.6 (SD 1.3), 5.6 (SD 1.0), and 8.8 (SD 0.9), respectively. Postoperative NRS scores also varied significantly, with worse outcomes observed in the severe group compared to the mild group, yet similar to the moderate group. A total of 46.8% of the mild group, 86.6% of the moderate group, and 72.9% of the severe group achieved a 50% decrease in NRS scores of LBP. Preoperative EQ-5D and ODI scores were significantly worse in the severe group compared to the mild or moderate groups, but postoperative scores were not significantly different between the severe and moderate groups. No significant differences in postoperative satisfaction were observed among the groups. Being female was a significant risk factor for less than 50% improvement in LBP (odds ratio = 1.56, p=.022).

CONCLUSIONS

Discectomy significantly improved LBP in patients with LDH, including those with moderate or severe LBP. Patients with severe LBP showed similar improvements in PROMs as those with moderate LBP. Female gender emerged as a significant risk factor for less than optimal improvement in LBP.

摘要

背景

腰椎间盘突出症(LDH)患者经常出现腰痛(LBP),然而椎间盘切除术改善腰痛的程度以及术前腰痛如何影响术后结果仍不清楚。

目的

评估腰痛的改善情况及其对术后患者报告结局指标(PROMs)的影响。

研究设计/设置:多中心回顾性观察研究。

患者样本

2017年4月至2021年3月期间在8家医院接受LDH椎间盘切除术的患者。

结局指标

收集患者的背景、手术因素和PROMs数据,包括腰部、臀部或腿部疼痛的数字评分量表(NRS)、欧洲五维健康量表(EQ-5D)、Oswestry功能障碍指数(ODI)评分以及术后满意度。

方法

患者被分为轻度(NRS 0-3)、中度(NRS 4-7)或重度(NRS 8-10)腰痛组。使用倾向得分的逆概率加权法来调整组间的人口统计学和临床差异。进行卡方检验和单因素方差分析以比较背景数据和临床特征。此外,进行多因素逻辑回归以确定腰痛改善不足50%的危险因素。

结果

本研究纳入928例患者:270例轻度、343例中度和315例重度。调整后,术前NRS评分在各组间有显著差异,分别为1.6(标准差1.3)、5.6(标准差1.0)和8.8(标准差0.9)。术后NRS评分也有显著差异,重度组与轻度组相比结果更差,但与中度组相似。轻度组中46.8%、中度组中86.6%、重度组中72.9%的患者腰痛NRS评分降低了50%。重度组术前EQ-5D和ODI评分显著差于轻度或中度组,但重度组与中度组术后评分无显著差异。各组术后满意度无显著差异。女性是腰痛改善不足50%的显著危险因素(比值比=1.56,p=0.022)。

结论

椎间盘切除术显著改善了LDH患者的腰痛,包括中度或重度腰痛患者。重度腰痛患者在PROMs方面的改善与中度腰痛患者相似。女性性别是腰痛改善未达最佳的显著危险因素。

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