Nilaweera Kanishka N, Nychyk Oleksandr, McCarthy William, Moreira Luiza P D, Alabedallat Qusai M, Purfied Deirdre, Doyle Jennifer, Cormican Paul, Santos Antonia, Yin Xiaofei, Tobin John, Speakman John R, Berry Donagh, Brennan Lorraine, Cotter Paul D
Food Bioscience Department, Teagasc Food Research Centre, Moorepark, County Cork, Fermoy, P61 C996, Ireland.
VistaMilk Research Centre, Teagasc, Moorepark, County Cork, Fermoy, P61 C996, Ireland.
Mol Nutr Food Res. 2024 Dec;68(23):e2400584. doi: 10.1002/mnfr.202400584. Epub 2024 Nov 3.
The study assesses the metabolic impact of dietary whey proteins across generations.
Virgin females are fed 20% energy whey proteins with 70% energy carbohydrates, which reduces body weight gain and visceral adipose compared to controls fed dietary casein. In contrast, the males are unresponsive. The effect is accentuated in reproductive females that also have reduced plasma levels of glucose. The responsive females have increased cecal levels of pyruvic and lactic acid, suggesting a greater catabolism of carbohydrates in the gut. While the male and female offspring born to mothers on whey proteins continue to reduce body weight gain, the female offspring further decreases the visceral and subcutaneous tissues and increases the gut capacity to breakdown dietary carbohydrates and proteins, whereas the male offspring are able to only decrease the visceral and increase protein catabolism in the gut. The ileum of male mice responded by reducing the gene expression for fibroblast growth factor 15 and increasing the expression of chymotrypsinogen B1.
The effect of whey proteins on growth can be passed from the mother to the offspring without a sex preference, whereas the transmission of gut activity and adiposity are dependent on the sex of the offspring.
本研究评估了不同代际中膳食乳清蛋白的代谢影响。
给未生育的雌性小鼠喂食含20%能量的乳清蛋白和70%能量的碳水化合物，与喂食酪蛋白的对照组相比，这减少了体重增加和内脏脂肪。相比之下，雄性小鼠没有反应。这种影响在生殖期雌性小鼠中更为明显，它们的血糖水平也有所降低。有反应的雌性小鼠盲肠中的丙酮酸和乳酸水平升高，表明肠道中碳水化合物的分解代谢增强。虽然食用乳清蛋白的母亲所生的雄性和雌性后代体重增加持续减少，但雌性后代进一步减少了内脏和皮下组织，并增加了肠道分解膳食碳水化合物和蛋白质的能力，而雄性后代仅能减少内脏脂肪并增加肠道中的蛋白质分解代谢。雄性小鼠的回肠通过降低成纤维细胞生长因子15的基因表达和增加胰凝乳蛋白酶原B1的表达做出反应。
乳清蛋白对生长的影响可以从母亲传递给后代，且无性别偏好，而肠道活性和肥胖的传递则取决于后代的性别。
