Ogden Sam C, Nishimura Marc T, Lapin Dmitry
Department of Biology, Colorado State University, Fort Collins, CO 80523, USA; Cell and Molecular Biology Graduate Program, Colorado State University, Fort Collins, CO 80523, USA.
Cell and Molecular Biology Graduate Program, Colorado State University, Fort Collins, CO 80523, USA.
Curr Opin Plant Biol. 2023 Oct 27;76:102481. doi: 10.1016/j.pbi.2023.102481.
Across the Tree of Life, innate immunity and cell death mechanisms protect hosts from potential pathogens. In prokaryotes, animals, and flowering plants, these functions are often mediated by Toll/interleukin-1 receptor (TIR) domain proteins. Here, we discuss recent analyses of TIR biology in flowering plants, revealing (i) TIR functions beyond pathogen recognition, e.g. in the spatial control of immunity, and (ii) the existence of at least two pathways for TIR signaling in plants. Also, we discuss TIR-based strategies for crop improvement and argue for a need to better understand TIR functions outside of commonly studied dicot pathways for future translational work. Opinions of experts on emerging topics in basic and translational plant TIR research are presented in supplementary video interviews.
在整个生命之树中，先天免疫和细胞死亡机制保护宿主免受潜在病原体的侵害。在原核生物、动物和开花植物中，这些功能通常由Toll/白细胞介素-1受体（TIR）结构域蛋白介导。在这里，我们讨论了开花植物中TIR生物学的最新分析，揭示了（i）TIR在病原体识别之外的功能，例如在免疫的空间控制中，以及（ii）植物中至少存在两条TIR信号传导途径。此外，我们讨论了基于TIR的作物改良策略，并认为有必要更好地了解TIR在常见研究的双子叶植物途径之外的功能，以便未来开展转化工作。补充视频访谈中展示了专家们对基础和转化植物TIR研究中新兴主题的看法。
