Wan Li
National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, 200032 China.
aBIOTECH. 2023 May 7;4(2):172-175. doi: 10.1007/s42994-023-00104-w. eCollection 2023 Jun.
The evolutionarily conserved Toll/Interleukin-1 Receptor (TIR) domains across kingdoms of prokaryotes, plants, and animals play critical roles in innate immunity. Recent studies have revealed the enzymatic functions of TIRs, the structural bases of TIRs as holoenzymes, and the identity of TIR-generated small signaling molecules and their receptors, which significantly advanced our understanding on TIR-mediated immune signaling pathways. We reviewed the most up-to-date findings in TIR enzymatic functions from the perspectives of signaling molecules and receptor mechanisms.
在原核生物、植物和动物界中进化保守的Toll/白细胞介素-1受体（TIR）结构域在先天免疫中发挥着关键作用。最近的研究揭示了TIR的酶功能、作为全酶的TIR的结构基础，以及TIR产生的小信号分子及其受体的特性，这显著推进了我们对TIR介导的免疫信号通路的理解。我们从信号分子和受体机制的角度综述了TIR酶功能的最新发现。
