Institute of Biomedical Engineering, University of Toronto, 164 College St., Toronto, Ontario, Canada, M5S 3G9.
Translational Biology and Engineering Program, Ted Rogers Centre for Heart Research, 661 University Ave., Toronto, Ontario, Canada, M5G 1M1.
Clin Sci (Lond). 2024 Nov 6;138(21):1395-1419. doi: 10.1042/CS20241084.
To maintain homeostasis in the heart, endothelial cells and cardiomyocytes engage in dynamic cross-talk through paracrine signals that regulate both cardiac development and function. Here, we review the paracrine signals that endothelial cells release to regulate cardiomyocyte growth, hypertrophy and contractility, and the factors that cardiomyocytes release to influence angiogenesis and vascular tone. Dysregulated communication between these cell types can drive pathophysiology of disease, as seen in ischemia-reperfusion injury, diabetes, maladaptive hypertrophy, and chemotherapy-induced cardiotoxicity. Investingating the role of cross-talk is critical in developing an understanding of tissue homeostasis, regeneration, and disease pathogenesis, with the potential to identify novel targets for diagnostic and therapeutic purposes.
为了维持心脏内环境稳定，内皮细胞和心肌细胞通过旁分泌信号进行动态交流，调节心脏发育和功能。在这里，我们回顾了内皮细胞释放的旁分泌信号，以调节心肌细胞的生长、肥大和收缩性，以及心肌细胞释放的调节血管生成和血管张力的因子。这些细胞类型之间通讯失调可导致疾病的病理生理学改变，如缺血再灌注损伤、糖尿病、适应性肥大和化疗诱导的心脏毒性。研究细胞间的交流作用对于理解组织内环境稳定、再生和疾病发病机制至关重要，并有潜力为诊断和治疗目的确定新的靶点。
