Peto Thomas J
Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, 10400.
Trans R Soc Trop Med Hyg. 2025 Feb 4;119(2):187-188. doi: 10.1093/trstmh/trae090.
This commentary discusses an influential study from 1993 that demonstrated, among West African children, an overall mortality benefit of insecticide-impregnated bednets, and the reduction of malaria prevalence by chemoprophylaxis. Led by Brian Greenwood and colleagues in The Gambia, the trial also showed these tools to be affordable and practicable. In the years since, >2 billion bednets have been provided to high-risk populations and have contributed greatly to reductions in malaria-attributable mortality. Seasonal malaria chemoprevention now protects 50 million African children annually. Few interventions in tropical medicine have achieved such an impact.
本评论讨论了一项1993年的有影响力的研究，该研究表明，在西非儿童中，使用杀虫剂处理过的蚊帐可带来总体死亡率降低的益处，以及通过化学预防可降低疟疾流行率。由冈比亚的布赖恩·格林伍德及其同事领导的这项试验还表明，这些工具价格实惠且切实可行。自那以后的数年里，已向高危人群提供了超过20亿顶蚊帐，这些蚊帐为降低疟疾所致死亡率做出了巨大贡献。季节性疟疾化学预防目前每年保护着5000万非洲儿童。热带医学领域很少有干预措施能取得如此大的成效。
