Tabolli S, Valtorta C, Bigi F, Minisola S, Mazzuoli G F
Horm Res. 1986;23(3):142-6. doi: 10.1159/000180309.
To investigate calcitonin secretion in primary hyperparathyroidism, basal and stimulated (3 mg Ca++/kg body weight/10 min) immunoreactive calcitonin plasma levels were studied before parathyroidectomy. Plasma calcitonin levels were raised in 50% of patients regardless of sex, but a significant correlation between basal plasma calcium and calcitonin was found only in males. A reduced calcitonin response to calcium infusion was observed in all patients. Parathyroidectomy invariably induced a normalization of calcitonin basal levels. Our findings confirm the existence of a decreased parafollicular cell reserve probably as a consequence of the persistent hypercalcemic state in hyperparathyroid patients and suggest that it is more frequent in females.
为研究原发性甲状旁腺功能亢进症中降钙素的分泌情况，在甲状旁腺切除术前，对基础及刺激状态（3毫克钙/千克体重/10分钟）下的血浆免疫反应性降钙素水平进行了研究。无论性别，50%的患者血浆降钙素水平升高，但仅在男性患者中发现基础血浆钙与降钙素之间存在显著相关性。所有患者对钙输注的降钙素反应均降低。甲状旁腺切除术总是能使降钙素基础水平恢复正常。我们的研究结果证实，甲状旁腺功能亢进患者由于持续的高钙血症状态，可能存在滤泡旁细胞储备减少的情况，并且提示这种情况在女性中更为常见。
