Aydın Merve, Köse Evren, Taşlıdere Karaca Elif, Tanbek Kevser, Sandal Süleyman
Department of Anatomy, Faculty of Medicine, Malatya Turgut Özal University, Malatya, Turkey.
Department of Anatomy, Faculty of Medicine, İnönü University, Malatya, Turkey.
Heliyon. 2024 Oct 15;10(20):e39386. doi: 10.1016/j.heliyon.2024.e39386. eCollection 2024 Oct 30.
The present study aims to explore the hepatoprotective potential of Lavandula stoechas (LS) against Bisphenol A (BPA)-induced liver toxicity. In this experiment, 32 male rats were utilized and categorized into control, LS, BPA, and BPA + LS groups for the study. Each group received 50 mg/kg of the respective substance. Throughout the 28-day experiment, the control group did not receive any applications. The LS oil was administered intraperitoneally, while BPA was given through oral gavage. At the end of the experiment, rats were anesthetized, and blood was taken from the heart. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total bilirubin (TB) values were measured from serum samples. Malondialdehyde (MDA), superoxide dismutase (SOD), total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) measurements were performed in liver tissue. The histological structure was observed using hematoxylin and eosin staining methods. The BPA group showed higher AST levels compared to the control group, but the BPA + LS group exhibited a significant decrease in AST levels compared to the BPA group. Additionally, TB levels were lower in the BPA + LS group compared to the BPA group. MDA levels increased in BPA-treated groups compared to others. The LS-treated groups showed higher SOD levels compared to the control group. Furthermore, an evident increase was noted in the BPA + LS group in comparison to the BPA group. The BPA group exhibited a significant rise in OSI value compared to the control. It was concluded that LS has a protective impact against BPA-induced liver toxicity. The LS-treated groups showed higher SOD levels compared to the control group. Furthermore, a significant increase was noted in the BPA + LS group in comparison to the BPA group. The BPA group exhibited a significant rise in OSI value compared to the control. It was concluded that LS has a protective impact against BPA-induced liver toxicity.
本研究旨在探讨薰衣草（Lavandula stoechas，LS）对双酚A（BPA）诱导的肝毒性的肝保护潜力。在本实验中，使用了32只雄性大鼠，并将其分为对照组、LS组、BPA组和BPA + LS组进行研究。每组接受50 mg/kg的相应物质。在整个28天的实验过程中，对照组未接受任何处理。LS油通过腹腔注射给药，而BPA通过灌胃给药。实验结束时，将大鼠麻醉，从心脏取血。从血清样本中测量丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）和总胆红素（TB）值。在肝组织中进行丙二醛（MDA）、超氧化物歧化酶（SOD）、总抗氧化状态（TAS）、总氧化状态（TOS）和氧化应激指数（OSI）的测量。使用苏木精和伊红染色方法观察组织学结构。与对照组相比，BPA组的AST水平较高，但与BPA组相比，BPA + LS组的AST水平显著降低。此外，与BPA组相比，BPA + LS组的TB水平较低。与其他组相比，BPA处理组的MDA水平升高。与对照组相比，LS处理组的SOD水平较高。此外，与BPA组相比，BPA + LS组有明显升高。与对照组相比，BPA组的OSI值显著升高。得出的结论是，LS对BPA诱导的肝毒性具有保护作用。与对照组相比，LS处理组的SOD水平较高。此外，与BPA组相比有显著升高。与对照组相比，BPA组的OSI值显著升高。得出的结论是，LS对BPA诱导的肝毒性具有保护作用。
