Tabacof Laura, Chiplunkar Maanas, Canori Alexandra, Howard Rebecca, Wood Jamie, Proal Amy, Putrino David
Cohen Center for Recovery from Complex Chronic Illness, Department of Rehabilitation and Human Performance, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Rusk Rehabilitation, Department of Physical Medicine and Rehabilitation, New York University Grossman School of Medicine, New York, NY, United States.
Front Rehabil Sci. 2024 Oct 18;5:1448816. doi: 10.3389/fresc.2024.1448816. eCollection 2024.
For many people with long COVID (LC), new-onset pain is a debilitating consequence. This study examined the nature of new-onset pain and concomitant symptoms in patients with LC to infer mechanisms of pain from the relationships between pain and health-related factors.
Pain and other symptoms were evaluated in 153 individuals with LC using the Self-Administered Leeds Assessment of Neuropathic Symptoms and Signs, EuroQoL Visual Analog Scale, and Quality of Life in Neurological Disorders. The relationships between pain and patient factors were analyzed using Chi Square and independent -tests.
20.3% of individuals who reported new-onset pain had neuropathic pain, which was associated with lower quality of life and higher rates of cognitive dysfunction compared to those with non-neuropathic pain. Other symptoms were similar between groups, however heart-related symptoms were more prevalent in individuals with neuropathic pain and mood swings were more prevalent for individuals with non-neuropathic pain.
Characterizing the relationships between NP and quality of life in individuals with LC can aid in developing better clinical management strategies. Understanding the associations between NP and cognitive dysfunction provides the imperative foundation for future studies further examining the pathophysiological mechanisms underlying pain development in LC.
对于许多长期新冠病毒感染（LC）患者而言，新发疼痛是一种使人衰弱的后果。本研究调查了LC患者新发疼痛的性质及伴随症状，以通过疼痛与健康相关因素之间的关系推断疼痛机制。
使用利兹神经病变症状和体征自评量表、欧洲生活质量视觉模拟量表以及神经疾病生活质量量表，对153例LC患者的疼痛及其他症状进行评估。采用卡方检验和独立样本t检验分析疼痛与患者因素之间的关系。
报告有新发疼痛的患者中，20.3%患有神经性疼痛，与非神经性疼痛患者相比，其生活质量较低，认知功能障碍发生率较高。两组之间的其他症状相似，但心脏相关症状在神经性疼痛患者中更为普遍，情绪波动在非神经性疼痛患者中更为普遍。
明确LC患者神经性疼痛（NP）与生活质量之间的关系有助于制定更好的临床管理策略。了解NP与认知功能障碍之间的关联为未来进一步研究LC疼痛发生的病理生理机制提供了必要的基础。
