早期胃复合型肿瘤，包含印戒细胞癌和黏膜相关淋巴组织淋巴瘤：一例报告。
Early gastric composite tumor comprising signet-ring cell carcinoma and mucosa-associated lymphoid tissue lymphoma: A case report.
机构信息
Department of Gastroenterology and Hepatology, University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
出版信息
World J Gastroenterol. 2024 Oct 14;30(38):4232-4238. doi: 10.3748/wjg.v30.i38.4232.
BACKGROUND
Composite tumors are neoplasms comprising two distinct, yet intermingling, cell populations. This paper reports a rare phenomenon where early gastric signet-ring cell carcinoma (SRCC) and gastric mucosa-associated lymphoid tissue (MALT) lymphoma coexist within the same lesion.
CASE SUMMARY
A 40-year-old woman presented to the West China Hospital for examination, which revealed a whitish, shallow, and uneven mucosal lesion in the stomach. The lesion was diagnosed as a poorly differentiated adenocarcinoma, including SRCC with atypical lymphoid hyperplasia associated with infection, based on histopathological examination of the biopsy specimen. The lesion was excised using segmental gastrectomy. However, histological examination of the surgical specimen confirmed that it was a poorly differentiated gastric adenocarcinoma with features of SRCC and MALT lymphoma. These two entities were stage I and coexisted in the same lesion.
CONCLUSION
It is uncommon for gastric SRCC and MALT lymphoma to coexist without distinct borders. Surgical resection is effective for these lesions.
背景
复合瘤是由两种不同但相互混合的细胞群体组成的肿瘤。本文报道了一种罕见现象，即同一病变内同时存在早期胃印戒细胞癌（SRCC）和胃黏膜相关淋巴组织（MALT）淋巴瘤。
病例摘要
一名 40 岁女性因胃部出现白色、浅而不均匀的黏膜病变到华西医院就诊。根据活检标本的组织病理学检查，该病变被诊断为低分化腺癌，包括 SRCC 和与 感染相关的不典型淋巴样增生。病变采用节段性胃切除术切除。然而，手术标本的组织学检查证实，这是一种低分化胃腺癌，具有 SRCC 和 MALT 淋巴瘤的特征。这两种实体均为 I 期，且共存于同一病变内。
结论
胃 SRCC 和 MALT 淋巴瘤没有明显边界共存的情况并不常见。手术切除对这些病变有效。
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