Human onchocerciasis is caused by the filarial worm. is a parasite that forms nodules under the skin. The aim of this work was to assess the nematicidal activities of on and and to determine the phytochemical compounds. Nodules were collected from the umbilical region of infected cattle, dissected and male worms were cultured in RPMI-1640. Worms were incubated with different concentrations of extracts in RPMI-1640 and M9-buffer. Polyphenol, tannin and flavonoid contents of extract were determined by using gallic acid and rutin as standards. The anthelmintic effect of extract against was concentration dependent with LC of 20.71 µg/mL and 11.75 µg/mL after 48 and 72 h respectively. extract exerted concentration dependent lethal effects (LC = 2747 and LC = 31,937 µg/mL) against (Wild Type). Methanolic-methylene chloride (MeOH-CHCl) of extract exhibited high DPPH activity with an IC value of 15 µg/mL and 9 µg/mL for ascorbic acid. The highest activity in adult worms was observed with the MeOH (100: 0) and AcOEtMeOH fractions with LC values of 12.82 and 15.50 µg/mL respectively. EcOEtMeOH (8:2 v/v) was more effective (LC = 250 µg/mL) on WT of contains polyphenols (1015.05 and AcOEtMeOH = 893.60), flavonoids (25.35 and MeOH = 225.76) and tannins (401.37 and Hex = 788.89). showed in vitro nematicidal activity against and . could be used as an alternative anthelmintic for onchocerciasis treatment.