De Broe M E, Bismuth C, De Groot G, Heath A, Okonek S, Ritz D R, Verpooten G A, Volans G N, Widdop B
Hum Toxicol. 1986 Jan;5(1):11-4. doi: 10.1177/096032718600500103.
Although it is many years since a haemodialysis and haemoperfusion over uncoated and later coated charcoal columns have been used for the treatment of intoxicated patients, the clinical efficacy of these extracorporeal techniques in the treatment of severely poisoned patients remains a matter of debate. Some of the reasons for this controversy may be the indiscriminate use of haemoperfusion in any form of intoxication, the lack of well-controlled studies and the wrong interpretation of the high haemoperfusion clearance values sometimes obtained. Simple pharmacokinetic principles are applied to this type of treatment and some practical guidelines as to how and when haemoperfusion should be applied or presented are reviewed. The limited place of haemoperfusion in the treatment of severe poisoning, its further declining use in the future, at least in its present design, and some promising new treatments are emphasized.
尽管使用未包被及后来包被的活性炭柱进行血液透析和血液灌流来治疗中毒患者已有多年，但这些体外技术在治疗重度中毒患者方面的临床疗效仍存在争议。造成这种争议的部分原因可能是在任何形式的中毒中都不加区分地使用血液灌流、缺乏严格对照研究以及有时对所获得的高血液灌流清除率值的错误解读。简单的药代动力学原理应用于这类治疗，并对血液灌流应如何及何时应用或呈现的一些实用指南进行了综述。强调了血液灌流在重度中毒治疗中的有限地位、其在未来（至少按其目前的设计）的使用进一步减少，以及一些有前景的新治疗方法。
