Hampel G, Crome P, Widdop B, Goulding R
Arch Toxicol. 1980 Jul;45(2):133-41. doi: 10.1007/BF01270911.
Fifteen patients who were severely poisoned with either hypnotic drugs or salicylate were treated by charcoal haemoperfusion. The device contained 100g of activated charcoal immobilised by fixation to a polyester film. Two patients showed no response and eventually died. The remainder showed marked lightening of coma and recovered uneventfully. Complications of platelet loss and, in one patient, fibrinolysis were observed, but these had no serious consequences. No significant biochemical disturbances occurred with the exception of one patient who presented with hypocalcaemia and required intravenous calcium throughout the treatment. Drug clearance values were comparable with those obtained with columns containing 300 g of acrylic polymer coated charcoal.
15名因催眠药物或水杨酸盐严重中毒的患者接受了活性炭血液灌注治疗。该装置包含100克通过固定在聚酯薄膜上而固定的活性炭。两名患者无反应，最终死亡。其余患者昏迷明显减轻，康复顺利。观察到有血小板减少的并发症，一名患者出现了纤维蛋白溶解，但这些均未造成严重后果。除一名出现低钙血症且在整个治疗过程中需要静脉补钙的患者外，未发生明显的生化紊乱。药物清除值与使用含有300克丙烯酸聚合物包被活性炭的柱所获得的值相当。
