Lectin-dependent cell-mediated cytotoxicity in an invertebrate model: Con A does not act as a bridge.
作者信息
Boswell C A, Bayne C J
出版信息
Immunology. 1986 Feb;57(2):261-4.
Abstract
The plant lectin concanavalin A (Con A) has been used in an invertebrate model of lectin-dependent cell-mediated cytotoxicity (LDCC). Macrophage-like cells from the susceptible host snail Biomphalaria glabrata become cytotoxic effectors when they encounter sporocysts of the parasitic trematode Schistosoma mansoni that have been treated with Con A. The sugar alpha-methyl mannoside and rabbit anti-Con A antibodies fail to block this LDCC. Con A is effective only when the target, not the effector cell, has been exposed to it. These results constitute evidence against the molecular bridging hypothesis and support the notion that surface modulation of the target may be the stimulus that provokes cytotoxicity. Results from this invertebrate model are discussed in the context of murine T lymphocyte LDCC.
摘要
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本文引用的文献
1
Schistosoma mansoni: ability of con A to protect in vitro mechanically transformed schistosomula against the lethal effect of immune serum plus complement.
Parasitology. 1982 Apr;84(Pt 2):239-52. doi: 10.1017/s0031182000044802.
2
Schistosoma mansoni: tegumental damage as a consequence of lectin binding.
Exp Parasitol. 1982 Feb;53(1):105-16. doi: 10.1016/0014-4894(82)90097-2.
3
Concanavalin A-induced receptor redistribution on Biomphalaria glabrata hemocytes: characterization of capping and patching responses.
J Invertebr Pathol. 1981 Jul;38(1):102-12. doi: 10.1016/0022-2011(81)90040-9.
4
T lymphocyte-mediated cytolysis. I. A common mechanism for target recognition in specific and lectin-dependent cytolysis.
J Immunol. 1981 Aug;127(2):776-81.
5
T lymphocyte-mediated cytolysis. II. Role of target cell histocompatibility antigens in recognition and lysis.
J Immunol. 1981 Aug;127(2):782-7.
6
Immune-recognition of Schistosoma mansoni primary sporocysts may require specific receptors on Biomphalaria glabrata hemocytes.
Parasite Immunol. 1984 Nov;6(6):519-28. doi: 10.1111/j.1365-3024.1984.tb00822.x.
7
Lectin-induced modulation of snail hemocyte surface determinants: clearance of Con A-receptor complexes.
Dev Comp Immunol. 1982 Summer;6(3):451-61. doi: 10.1016/s0145-305x(82)80031-1.
8
The effects of concanavalin A on the mobility of lymphocyte surface receptors.
Exp Cell Res. 1973 Sep;81(1):143-55. doi: 10.1016/0014-4827(73)90121-3.
9
Schistosoma mansoni: lectin-dependent cytotoxicity of hemocytes from susceptible host snails, Biomphalaria glabrata.
Exp Parasitol. 1985 Aug;60(1):133-8. doi: 10.1016/s0014-4894(85)80030-8.
10
Genetic factors in susceptibility of Biomphalaria glabrata for different strains of Schistosoma mansoni.
Parasitology. 1975 Apr;70(2):231-41. doi: 10.1017/s0031182000049696.
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