无脊椎动物模型中的凝集素依赖性细胞介导的细胞毒性：伴刀豆球蛋白A不充当桥梁。
Lectin-dependent cell-mediated cytotoxicity in an invertebrate model: Con A does not act as a bridge.
作者信息
Boswell C A, Bayne C J
出版信息
Immunology. 1986 Feb;57(2):261-4.
Abstract
The plant lectin concanavalin A (Con A) has been used in an invertebrate model of lectin-dependent cell-mediated cytotoxicity (LDCC). Macrophage-like cells from the susceptible host snail Biomphalaria glabrata become cytotoxic effectors when they encounter sporocysts of the parasitic trematode Schistosoma mansoni that have been treated with Con A. The sugar alpha-methyl mannoside and rabbit anti-Con A antibodies fail to block this LDCC. Con A is effective only when the target, not the effector cell, has been exposed to it. These results constitute evidence against the molecular bridging hypothesis and support the notion that surface modulation of the target may be the stimulus that provokes cytotoxicity. Results from this invertebrate model are discussed in the context of murine T lymphocyte LDCC.
摘要
植物凝集素伴刀豆球蛋白A（Con A）已被用于凝集素依赖性细胞介导的细胞毒性（LDCC）的无脊椎动物模型。来自易感宿主蜗牛光滑双脐螺的类巨噬细胞在遇到经Con A处理的寄生吸虫曼氏血吸虫的子胞蚴时会成为细胞毒性效应器。α-甲基甘露糖苷和兔抗Con A抗体无法阻断这种LDCC。Con A仅在靶细胞而非效应细胞暴露于它时才有效。这些结果构成了反对分子桥接假说的证据，并支持这样一种观点，即靶细胞的表面调节可能是引发细胞毒性的刺激因素。在小鼠T淋巴细胞LDCC的背景下讨论了这个无脊椎动物模型的结果。
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