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在一名接受体外循环冠状动脉搭桥手术的重度甲型血友病患者中推注和持续输注凝血因子VIII的联合应用。

Combination of bolus and continuous infusion of factor VIII in a patient with severe hemophilia A undergoing on-pump coronary artery bypass graft surgery.

作者信息

Vander Zwaag Stanislaw, Brose Stefan, Fassl Jens

机构信息

Department of Cardiac Anesthesiology, Heart Center Dresden University Hospital Dresden Germany.

Department of Cardiac Surgery, Heart Center Dresden University Hospital Dresden Germany.

出版信息

Clin Case Rep. 2024 Nov 1;12(11):e9468. doi: 10.1002/ccr3.9468. eCollection 2024 Nov.

DOI:10.1002/ccr3.9468
PMID:39493790
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11530351/
Abstract

Patients with hemophilia A can safely undergo cardiac surgery. Combining continuous infusion and boluses of factor VIII is both safe and cost-effective. Interdisciplinary approach and meticulous planning are crucial in the prevention of bleeding complications.

摘要

甲型血友病患者可安全地接受心脏手术。联合持续输注和大剂量注射凝血因子 VIII 既安全又具成本效益。多学科方法和精心规划对预防出血并发症至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6277/11530351/af3a89335df5/CCR3-12-e9468-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6277/11530351/27c288149f08/CCR3-12-e9468-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6277/11530351/65a0f3277677/CCR3-12-e9468-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6277/11530351/af3a89335df5/CCR3-12-e9468-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6277/11530351/27c288149f08/CCR3-12-e9468-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6277/11530351/65a0f3277677/CCR3-12-e9468-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6277/11530351/af3a89335df5/CCR3-12-e9468-g001.jpg

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本文引用的文献

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Mortality, life expectancy, and causes of death of persons with hemophilia in the Netherlands 2001-2018.2001 - 2018年荷兰血友病患者的死亡率、预期寿命及死因
J Thromb Haemost. 2021 Mar;19(3):645-653. doi: 10.1111/jth.15182. Epub 2020 Dec 18.
2
Hemophilia: A Review of Perioperative Management for Cardiac Surgery.血友病：心脏手术围手术期管理综述。
J Cardiothorac Vasc Anesth. 2022 Jan;36(1):246-257. doi: 10.1053/j.jvca.2020.09.118. Epub 2020 Sep 22.
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WFH Guidelines for the Management of Hemophilia, 3rd edition.《血友病管理的居家指南》第三版
Haemophilia. 2020 Aug;26 Suppl 6:1-158. doi: 10.1111/hae.14046. Epub 2020 Aug 3.
4
Perioperative Management of Hemophilia A Patients Undergoing Cardiac Surgery: A Literature Review of Published Cases.围手术期管理 A 型血友病患者心脏手术：文献复习发表的病例。
J Cardiothorac Vasc Anesth. 2021 May;35(5):1341-1350. doi: 10.1053/j.jvca.2020.06.074. Epub 2020 Jun 27.
5
The World Federation of Hemophilia Annual Global Survey 1999-2018.《世界血友病联盟 1999-2018 年全球年度调查》。
Haemophilia. 2020 Jul;26(4):591-600. doi: 10.1111/hae.14012. Epub 2020 Jun 4.
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Cardiac surgery in patients with Hemophilia:is it safe?血友病患者的心脏手术：安全吗？
J Cardiothorac Surg. 2020 May 8;15(1):76. doi: 10.1186/s13019-020-01123-0.
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The definition, diagnosis and management of mild hemophilia A: communication from the SSC of the ISTH.轻度甲型血友病的定义、诊断与管理：来自国际血栓与止血学会（ISTH）科学标准化委员会的交流文件
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