Dutta Pritha, Layton Anita T
Department of Applied Mathematics, University of Waterloo, Waterloo, ON N2L 3G1, Canada.
Department of Biology, University of Waterloo, Waterloo, ON N2L 3G1, Canada.
iScience. 2024 Sep 30;27(11):111077. doi: 10.1016/j.isci.2024.111077. eCollection 2024 Nov 15.
Magnesium (Mg) is crucial for several cellular and physiological processes and is tightly regulated due to health risks associated with imbalances. Mg, calcium (Ca), parathyroid hormone, and vitamin D are tightly coupled, ensuring proper bone metabolism and intestinal and renal absorption of Mg and Ca. While several Ca homeostasis models exist, no computational model has been developed to study Mg homeostasis. We developed a computational model of Mg homeostasis in male rats, integrating it with an existing Ca homeostasis model, to understand the interconnected physiological processes regulating their homeostasis. We then analyzed adaptations in these interconnected processes under (1) dietary Mg deficiency, (2) low/high dietary Ca with Mg deficiency, and (3) vitamin D deficiency. Model simulations predicted severe hypomagnesemia and mild hypocalcemia with significant dietary Mg deficiency. Low dietary Ca improved, while high dietary Ca worsened Mg deficiency. Finally, vitamin D deficiency caused severe hypocalcemia, with minimal impact on Mg homeostasis.
镁（Mg）对多种细胞和生理过程至关重要，由于与失衡相关的健康风险，其受到严格调控。镁、钙（Ca）、甲状旁腺激素和维生素D紧密相关，确保适当的骨代谢以及镁和钙的肠道及肾脏吸收。虽然存在几种钙稳态模型，但尚未开发出用于研究镁稳态的计算模型。我们建立了雄性大鼠镁稳态的计算模型，并将其与现有的钙稳态模型相结合，以了解调节它们稳态的相互关联的生理过程。然后，我们分析了在以下三种情况下这些相互关联过程的适应性变化：（1）饮食中镁缺乏；（2）低/高钙饮食且伴有镁缺乏；（3）维生素D缺乏。模型模拟预测，严重的饮食镁缺乏会导致严重的低镁血症和轻度的低钙血症。低钙饮食可改善镁缺乏状况，而高钙饮食则会加重镁缺乏。最后，维生素D缺乏会导致严重的低钙血症，对镁稳态的影响最小。
