Department of Microbiology, School of Life Sciences, Central University of Tamil Nadu, Tiruvarur, TN 610005, India.
School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong 999077, China.
World J Gastroenterol. 2024 Oct 28;30(40):4404-4410. doi: 10.3748/wjg.v30.i40.4404.
Hyperuricemia (HUA) is a condition associated with a high concentration of uric acid (UA) in the bloodstream and can cause gout and chronic kidney disease. The gut microbiota of patients with gout and HUA is significantly altered compared to that of healthy people. This article focused on the complex interconnection between alterations in the gut microbiota and the development of this disorder. Some studies have suggested that changes in the composition, diversity, and activity of microbes play a key role in establishing and progressing HUA and gout pathogenesis. Therefore, we discussed how the gut microbiota contributes to HUA through purine metabolism, UA excretion, and intestinal inflammatory responses. We examined specific changes in the composition of the gut microbiota associated with gout and HUA, highlighting key bacterial taxa and the metabolic pathways involved. Additionally, we discussed the effect of conventional gout treatments on the gut microbiota composition, along with emerging therapeutic approaches that target the gut microbiome, such as the use of probiotics and prebiotics. We also provided insights into a study regarding the gut microbiota as a possible novel therapeutic intervention for gout treatment and dysbiosis-related diagnosis.
高尿酸血症（HUA）是一种与血液中尿酸（UA）浓度升高有关的病症，可导致痛风和慢性肾病。与健康人相比，痛风和 HUA 患者的肠道微生物群有明显改变。本文重点关注肠道微生物群的改变与这种疾病发展之间的复杂联系。一些研究表明，微生物组成、多样性和活性的变化在建立和发展 HUA 和痛风发病机制方面起着关键作用。因此，我们讨论了肠道微生物群如何通过嘌呤代谢、UA 排泄和肠道炎症反应导致 HUA。我们检查了与痛风和 HUA 相关的肠道微生物群组成的特定变化，突出了关键的细菌分类群和涉及的代谢途径。此外，我们还讨论了常规痛风治疗对肠道微生物群组成的影响，以及针对肠道微生物组的新兴治疗方法，例如使用益生菌和益生元。我们还提供了一项关于肠道微生物群作为痛风治疗和与肠道菌群失调相关诊断的潜在新型治疗干预措施的研究的见解。
