Zhao Shuai, Feng Pengya, Hu Xiaogang, Cao Wenjuan, Liu Pu, Han Huawen, Jin Weilin, Li Xiangkai
Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000, Gansu Province, P. R. China.
Pingliang Rehabilitation Center Hospital, No. 23 Taitong Road, Kongtong District, Pingliang 744000, People's Republic of China.
iScience. 2022 Sep 28;25(10):105198. doi: 10.1016/j.isci.2022.105198. eCollection 2022 Oct 21.
Probiotics have demonstrated the potential to ameliorate hyperuricemia in animals, but their effectiveness and mechanism of action in humans has been understudied. A randomized, double-blinded, controlled research was conducted with 120 volunteers, who consume either a probiotic yogurt containing a UA-degrading strain GR-3 or a conventional yogurt for 2 months, to investigate probiotic yogurt helped decrease uric acid levels in the at-risk human population. Serum UA levels showed that the probiotic yogurt caused a significant decrease than the consumption of conventional yogurt (26.2% ± 2.3% vs. 8.6% ± 1.1%), and contributed to the UA excretion in the feces and urine (7.4% ± 2.1% and 13.8% ± 3.4%, respectively, 1.9% ± 1.1% and 5.1% ± 2.2%, respectively). Metabolomics and microbial community analysis showed a positive correlation with enhanced anti-inflammation of the host. Our findings suggest an effective and economical therapeutic adjuvant in treating hyperuricemia.
益生菌已显示出在动物中改善高尿酸血症的潜力，但其在人类中的有效性和作用机制尚未得到充分研究。对120名志愿者进行了一项随机、双盲、对照研究，他们分别食用含有尿酸降解菌株GR-3的益生菌酸奶或传统酸奶2个月，以调查益生菌酸奶是否有助于降低高危人群的尿酸水平。血清尿酸水平显示，与食用传统酸奶相比，益生菌酸奶导致尿酸水平显著降低（分别为26.2%±2.3%和8.6%±1.1%），并促进粪便和尿液中的尿酸排泄（分别为7.4%±2.1%和13.8%±3.4%，传统酸奶分别为1.9%±1.1%和5.1%±2.2%）。代谢组学和微生物群落分析表明，这与宿主抗炎作用增强呈正相关。我们的研究结果表明，益生菌酸奶是治疗高尿酸血症的一种有效且经济的治疗辅助手段。
