Lou Heqing, Jiang Yixue, Xu Chunrong, Dong Zong-Mei, Liu De, Qiao Cheng, Zhang Pan
Department of Control and Prevention of Chronic Non-communicable Diseases, Xuzhou Center for Disease Control and Prevention, Xuzhou, Jiangsu, China.
Department of Endocrinology, Xuzhou Cancer Hospital, Xuzhou, Jiangsu, China.
SAGE Open Med. 2024 Oct 31;12:20503121241265066. doi: 10.1177/20503121241265066. eCollection 2024.
Both dyslipidemia and hypertension contribute to poor glycemic control in patients with type 2 diabetes mellitus, but the combined effect of dyslipidemia and hypertension on glycemic control in patients with type 2 diabetes mellitus has not been evaluated. The aim of this study was to analyze the interaction effect between dyslipidemia and hypertension on glycemic control in patients with type 2 diabetes mellitus.
A total of 2485 patients with type 2 diabetes mellitus were selected from the Xuzhou community of China by multi-stage cluster random sampling for a cross-sectional survey. Their glycated hemoglobin, dyslipidemia, and hypertension were assessed, and the interaction effects between dyslipidemia and hypertension on glycemic control were analyzed using relative excess risk due to the interaction, the synergy index, and the attributable proportion of the additive interaction.
Of the participants, 62.13% (1544/2485) had dyslipidemia and 55.01% (1367/2485) had hypertension. Of the participants, 76.66% (1905/2485) who had both dyslipidemia and hypertension also had poor glycemic control. The prevalence of poor glycemic control was higher in those with both dyslipidemia and hypertension (odds ratio 2.735, 95% confidence interval 2.117-3.532; < 0.001) compared with those who had normal blood lipids and without hypertension, after adjustment for confounders. The relative excess risk due to the interaction, the attributable proportion, and the synergy index were 1.077 (95% confidence interval 0.558-1.596), 2.637 (95% confidence interval 1.268-4.006), and 0.394 (95% confidence interval 0.230-0.558), respectively, for the interaction between dyslipidemia and hypertension.
Dyslipidemia and hypertension have an additive interaction on poor glycemic control in patients with type 2 diabetes mellitus.
血脂异常和高血压均会导致2型糖尿病患者血糖控制不佳，但血脂异常和高血压对2型糖尿病患者血糖控制的联合作用尚未得到评估。本研究旨在分析血脂异常和高血压对2型糖尿病患者血糖控制的交互作用。
通过多阶段整群随机抽样从中国徐州社区选取2485例2型糖尿病患者进行横断面调查。评估他们的糖化血红蛋白、血脂异常和高血压情况，并使用交互作用导致的相对超额危险度、协同指数和相加交互作用的归因比例分析血脂异常和高血压对血糖控制的交互作用。
参与者中，62.13%（1544/2485）患有血脂异常，55.01%（1367/2485）患有高血压。在同时患有血脂异常和高血压的参与者中，76.66%（1905/2485）血糖控制也不佳。在调整混杂因素后，与血脂正常且无高血压的患者相比，同时患有血脂异常和高血压的患者血糖控制不佳的患病率更高（比值比2.735，95%置信区间2.117 - 3.532；P < 0.001）。血脂异常和高血压交互作用导致的相对超额危险度、归因比例和协同指数分别为1.077（95%置信区间0.558 - 1.596）、2.637（95%置信区间1.268 - 4.006）和0.394（95%置信区间0.230 - 0.558）。
血脂异常和高血压对2型糖尿病患者血糖控制不佳具有相加交互作用。
