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帕博利珠单抗诱发的细胞因子释放综合征伴透明细胞阴道癌患者出现严重脑病：一例报告

Pembrolizumab-induced cytokine release syndrome with severe encephalopathy in the setting of clear cell vaginal carcinoma: A case report.

作者信息

Metzger Samantha, Ulmer Keely, Hill Emily K

机构信息

Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, United States.

出版信息

Gynecol Oncol Rep. 2024 Oct 11;56:101529. doi: 10.1016/j.gore.2024.101529. eCollection 2024 Dec.

DOI:10.1016/j.gore.2024.101529
PMID:39494393
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11530849/
Abstract

•Pembrolizumab is increasingly used in the treatment of gynecologic cancers and has a half-life of 26 days.•Cytokine release syndrome with severe encephalopathy is a rare immune-mediated adverse effect.•Supportive care remains an important part of treatment of immune-mediated toxicity. It takes 5 half-lives to clear Pembrolizumab from the body.

摘要

•帕博利珠单抗越来越多地用于治疗妇科癌症，其半衰期为26天。•伴有严重脑病的细胞因子释放综合征是一种罕见的免疫介导不良反应。•支持性治疗仍然是免疫介导毒性治疗的重要组成部分。帕博利珠单抗从体内清除需要5个半衰期。

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Pembrolizumab-induced cytokine release syndrome with severe encephalopathy in the setting of clear cell vaginal carcinoma: A case report.帕博利珠单抗诱发的细胞因子释放综合征伴透明细胞阴道癌患者出现严重脑病：一例报告
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本文引用的文献

1
A complete durable response of vaginal clear cell carcinoma with pembrolizumab: A case report.帕博利珠单抗治疗阴道透明细胞癌的完全持久缓解：一例报告
Gynecol Oncol Rep. 2023 Mar 11;49:101160. doi: 10.1016/j.gore.2023.101160. eCollection 2023 Oct.
2
Dostarlimab for Primary Advanced or Recurrent Endometrial Cancer.度伐利尤单抗治疗原发性晚期或复发性子宫内膜癌。
N Engl J Med. 2023 Jun 8;388(23):2145-2158. doi: 10.1056/NEJMoa2216334. Epub 2023 Mar 27.
3
Pembrolizumab plus Chemotherapy in Advanced Endometrial Cancer.帕博利珠单抗联合化疗治疗晚期子宫内膜癌。
N Engl J Med. 2023 Jun 8;388(23):2159-2170. doi: 10.1056/NEJMoa2302312. Epub 2023 Mar 27.
4
Pembrolizumab-induced encephalitis in a patient with renal cell carcinoma post nephrectomy: A case report.肾切除术后肾细胞癌患者发生的帕博利珠单抗诱发的脑炎：一例报告
SAGE Open Med Case Rep. 2023 Jan 17;11:2050313X221149827. doi: 10.1177/2050313X221149827. eCollection 2023.
5
Cytokine release syndrome induced by pembrolizumab: A case report.帕博利珠单抗引起的细胞因子释放综合征：一例报告。
Medicine (Baltimore). 2022 Dec 9;101(49):e31998. doi: 10.1097/MD.0000000000031998.
6
Cytokine Release Syndrome in Cancer Patients Receiving Immune Checkpoint Inhibitors: A Case Series of 25 Patients and Review of the Literature.免疫检查点抑制剂治疗的癌症患者细胞因子释放综合征：25 例患者的病例系列及文献复习。
Front Immunol. 2022 Jan 28;13:807050. doi: 10.3389/fimmu.2022.807050. eCollection 2022.
7
[Pembrolizumab-associated autoimmune encephalitis in an elderly patient with advanced non-small cell lung cancer. A clinical case].[一名晚期非小细胞肺癌老年患者的帕博利珠单抗相关自身免疫性脑炎。临床病例]
An Sist Sanit Navar. 2021 Aug 20;44(2):291-297. doi: 10.23938/ASSN.0948.
8
Encephalitis induced by immune checkpoint inhibitors in metastatic melanoma: a monocentric retrospective study.免疫检查点抑制剂诱发的转移性黑色素瘤脑炎：一项单中心回顾性研究
J Eur Acad Dermatol Venereol. 2019 Dec;33(12):e440-e443. doi: 10.1111/jdv.15756. Epub 2019 Jul 26.
9
Efficacy and Safety of Pembrolizumab in Previously Treated Advanced Cervical Cancer: Results From the Phase II KEYNOTE-158 Study.帕博利珠单抗治疗既往治疗的晚期宫颈癌的疗效和安全性：来自 II 期 KEYNOTE-158 研究的结果。
J Clin Oncol. 2019 Jun 10;37(17):1470-1478. doi: 10.1200/JCO.18.01265. Epub 2019 Apr 3.
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Pembrolizumab-induced autoimmune encephalitis in a patient with advanced non-small cell lung cancer: A case report.帕博利珠单抗诱导的晚期非小细胞肺癌患者自身免疫性脑炎：一例报告
Mol Clin Oncol. 2019 Feb;10(2):267-269. doi: 10.3892/mco.2018.1777. Epub 2018 Nov 27.