Integrative Human Physiology Laboratory, Manning College of Nursing & Health Sciences University of Massachusetts Boston Boston MA USA.
Department of Exercise and Health Sciences University of Massachusetts Boston Boston MA USA.
J Am Heart Assoc. 2024 Nov 5;13(21):e036107. doi: 10.1161/JAHA.124.036107. Epub 2024 Nov 4.
Black compared with White adults have a higher risk for left-ventricular hypertrophy and heart failure possibly due to the early onset of alterations in ventricular-vascular coupling (ie, arterial [] to ventricular elastance [] ratio) and wasted pressure effort (). Aerobic training preserves the coupling ratio (/) and attenuates , but whether this applies to Black adults is unknown. We hypothesized that Black rather than White adults would have greater training-induced improvements in the / and .
Fifty-four young adults with normal blood pressure (Black=24 [58% female]; White=30 [47% female], mean=24 years; SD=5 years) completed an 8-week aerobic training (3 times/week, 65%-85% peak oxygen uptake). / was estimated via echocardiography and scaled to body surface area, and the was estimated from pulse contour analysis. Black adults had lower / (difference ()=0.49 [95% CI, 0.14-0.84 mm Hg/mL], =0.007) and higher (=1127 [95% CI, 104-2007 dyne cm s], =0.005). Both groups exhibited similar (race-by-training interaction, =0.986) training-induced reductions in scaled (=-0.11 [95% CI, -0.18 to -0.04 mm Hg/mL], <0.001). Only in White adults, scaled increased (=0.39 [95% CI, 0.11-0.32 mm Hg/mL], =0.003) and / was reduced (=-0.16 [95% CI, -0.33 to -0.18 mm Hg/mL/m], <0.001). Conversely, only Black adults exhibited reductions in after training (=-699 [95% CI, -1209 to -189 dyne cm s], =0.008).
Aerobic training-induced differential effects on / and of White and Black young adults hold the potential to reduce racial disparities. This warrants confirmation in a larger sample.
URL: https://www.clinicaltrials.gov; Unique identifier: NCT01024634.
与白人成年人相比，黑人成年人患左心室肥大和心力衰竭的风险更高，这可能是由于心室-血管耦联（即动脉[]与心室弹性[]的比值）和浪费压力的早期改变所致。有氧运动训练可以保持耦合比（/）并减轻，但这种情况是否适用于黑人成年人尚不清楚。我们假设黑人成年人而非白人成年人在训练后/比值和比值的改善程度会更大。
54 名血压正常的年轻人（黑人=24 名[58%为女性]；白人=30 名[47%为女性]，平均年龄 24 岁；标准差 5 岁）完成了 8 周的有氧运动训练（每周 3 次，占峰值摄氧量的 65%-85%）。通过超声心动图估计/，并按体表面积进行缩放，通过脉搏轮廓分析估计。黑人成年人的/比值较低（差异（）=0.49 [95%置信区间，0.14-0.84 毫米汞柱/毫升]，=0.007），而值较高（=1127 [95%置信区间，104-2007 达因·厘米·秒]，=0.005）。两组均表现出相似的训练诱导（种族与训练的交互作用，=0.986）/比值降低。仅在白人成年人中，按比例缩小的/增加（=0.39 [95%置信区间，0.11-0.32 毫米汞柱/毫升]，<0.001），而/比值降低（=-0.16 [95%置信区间，-0.33 至-0.18 毫米汞柱/毫升/米]，<0.001）。相反，只有黑人成年人在训练后/比值降低（=-699 [95%置信区间，-1209 至-189 达因·厘米·秒]，=0.008）。
有氧运动训练对白人青年和黑人青年的/比值和比值的不同影响可能会减少种族差异。这需要在更大的样本中进行确认。
