Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
Medical School, Faculdade Ciências Médicas de Minas Gerais, Belo Horizonte, Brazil.
Oral Maxillofac Surg. 2024 Nov 4;29(1):4. doi: 10.1007/s10006-024-01296-1.
Conventional ameloblastoma presents infiltrative behavior and its treatment ranges from enucleation combined with adjuvant therapies to marginal/segmental resection. The purpose of this study is to present a cohort of twenty-four patients with ameloblastoma treated in the same institution after marginal/segmental resection for the past 21 years. All cases had diagnosis confirmation by incisional biopsy. Patients with an unconfirmed diagnosis and missing follow-up information were excluded. Data were categorized into clinicopathological, surgical and recurrence aspects. Thirteen patients were females (54%). The mean age was 40.2 years. Mandible was the most affected site (91%). The mean length of the lesions was 4.10 cm (± 2.06) and the multilocular aspect was predominant (83%). Root resorption (37.5%), tooth displacement (45.8%) and cortical perforation (45.8%) were noticed. Histologically, most of the cases were follicular (n = 19,79%). Microscopic analysis showed positive margins in four cases. Patients were treated by marginal (n = 19) and segmental (n = 5) resections. Recurrence occurred in two cases (8.33%). Both primary and recurrent ameloblastomas were treated through marginal resections and no recurrence was observed during the past 9 and 5 years after the last intervention, respectively. The overall mean follow-up was 79.25 months and patients are still monitored over these years. Marginal/segmental resection of conventional ameloblastoma is associated with a low recurrence rate.
传统型成釉细胞瘤呈浸润性生长，其治疗方法范围从肿瘤剜除术联合辅助治疗到边缘/节段切除术。本研究的目的是报告过去 21 年在同一机构接受边缘/节段切除术治疗的 24 例成釉细胞瘤患者的队列。所有病例均通过切开活检确诊。排除未确诊和随访信息缺失的病例。数据分为临床病理、手术和复发方面。13 例为女性（54%）。平均年龄为 40.2 岁。下颌骨是最常受影响的部位（91%）。病变的平均长度为 4.10 cm（±2.06），多房型为主（83%）。发现根吸收（37.5%）、牙齿移位（45.8%）和皮质穿孔（45.8%）。组织学上，大多数病例为滤泡型（n=19，79%）。显微镜下分析显示 4 例有阳性切缘。患者接受了边缘（n=19）和节段（n=5）切除术治疗。2 例（8.33%）发生复发。原发性和复发性成釉细胞瘤均通过边缘切除术治疗，末次干预后 9 年和 5 年分别未见复发。总的平均随访时间为 79.25 个月，这些年来患者仍在接受监测。传统型成釉细胞瘤的边缘/节段切除术复发率低。
