Institut de Recherche Clinique du Bénin (IRCB), Abomey-Calavi, Benin.
Institut Agro, UMR MoISA, University Montpellier, CIRAD, CIHEAM-IAMM, INRAe, IRD, Montpellier, France.
PLoS One. 2024 Nov 4;19(11):e0312840. doi: 10.1371/journal.pone.0312840. eCollection 2024.
Accurate determination of pre-pregnancy weight is essential for optimal pregnancy monitoring and antenatal care. Determining pre-pregnancy weight in limited-resources settings is challenging for both clinical practice and public health research. From a 2014-2017 pre-pregnancy cohort in Benin, we evaluated the agreement between the measured pre-pregnancy weight (MPPW) and two proxies: (i) the first trimester pregnancy weight (FTPW) and (ii) the estimated pre-pregnancy weight (EPPW) using Thomas & al. formula. We analysed data from 302 pregnant women with both pre-pregnancy weight measured within 3 months before conception and weight measured during the first trimester. Using segmented linear regression, we first assessed up to which gestational age the weight measured during the first trimester could reasonably estimate the MPPW. Then the Bland & Altman method was used to assess agreement between MPPW and the two proxies. Additional analyses were performed to assess the sensitivity of results to the timing of measurement of either MPPW or the two proxies. On average, FTPW did not feature significant difference with MPPW up to 13.03 (11.99-14.06) weeks of gestational age. FTPW, measured on average at 7 ± 2.4 weeks of gestation, and the EPPW showed similar Bland & Altman limits of agreement with the MPPW. However, while the FTPW slightly underestimated the MPPW by a mean of-0.16 (-0.08; +0.39) kg, the EPPW overestimated it by a mean of + 0.43 (+0.20; +0.66) kg. Minor differences in these results were observed when the MPPW was assessed earlier or within three months before pregnancy, or according to the gestational age at the time of the proxy's measurement. In conclusion, in Southern Benin and up to 12-14 weeks of pregnancy, the FTPW appeared to be a good proxy of the MPPW while using Thomas' formula did not enhance pre-pregnancy weight estimation.
准确确定孕前体重对于优化妊娠监测和产前保健至关重要。在资源有限的情况下，无论是临床实践还是公共卫生研究，确定孕前体重都具有挑战性。本研究评估了在贝宁，2014 年至 2017 年的一个孕前队列中，测量的孕前体重（MPPW）与两个代理变量（i）孕早期妊娠体重（FTPW）和（ii）基于托马斯等人公式的估计孕前体重（EPPW）之间的一致性。我们分析了 302 名孕妇的数据，这些孕妇在受孕前 3 个月内测量了孕前体重，并且在孕早期测量了体重。使用分段线性回归，我们首先评估了在孕早期测量的体重在多大程度上可以合理估计 MPPW。然后使用 Bland 和 Altman 方法评估 MPPW 与两个代理变量之间的一致性。进行了额外的分析，以评估 MPPW 或两个代理变量的测量时间对结果的敏感性。平均而言，FTPW 在妊娠 13.03 周（11.99-14.06 周）之前与 MPPW 没有显著差异。FTPW 平均在妊娠 7±2.4 周时测量，EPPW 与 MPPW 具有相似的 Bland 和 Altman 一致性界限。然而，FTPW 平均低估了 MPPW-0.16（-0.08；+0.39）kg，EPPW 平均高估了 MPPW+0.43（0.20；+0.66）kg。当更早或在怀孕前三个月内评估 MPPW 时，或者根据代理变量测量时的孕龄，这些结果存在微小差异。总之，在贝宁南部地区，直到妊娠 12-14 周，FTPW 似乎是 MPPW 的良好代理变量，而使用托马斯公式并没有提高孕前体重估计值。
