Murphy D J, Memula N, Doss L L
Int J Radiat Oncol Biol Phys. 1986 Feb;12(2):267-70. doi: 10.1016/0360-3016(86)90108-2.
Nomograms for square planar arrays spanning the range from 3 X 3 cm to 10 X 10 cm were developed. The nomograms are intended to be used for pretreatment planning of implant geometry, so that the therapist may enter the operating room with a plan for the optimal implant in mind. We show that clinically useful implants are those in which the reference isodoses are fully coupled. Decoupling occurs when ribbon spacing exceeds approximately 1.2 cm and leads to undesirable "cold spots" within the treatment volume. Ribbon spacing of 1.0 cm is recommended. This represents a trade-off between adequate ribbon coupling and minimum tissue damage from trocar placement. For clinically useful arrays, the area enclosed by the reference isodose contour (85% of the maximum dose rate) is approximately 50% of the array area. Reference isodose contour and its enclosed area are independent of seed strength for a given array, as long as all seeds within the array are of equal strength.
已开发出适用于边长范围从3×3厘米至10×10厘米的方形平面阵列的列线图。这些列线图旨在用于植入物几何形状的预处理规划，以便治疗师在进入手术室时心中有一个关于最佳植入物的计划。我们表明，临床上有用的植入物是那些参考等剂量线完全耦合的植入物。当带间距超过约1.2厘米时会发生解耦，并在治疗体积内导致不良的“冷点”。建议带间距为1.0厘米。这代表了在足够的带耦合与套管针放置造成的最小组织损伤之间的权衡。对于临床上有用的阵列，参考等剂量线轮廓（最大剂量率的85%）所包围的面积约为阵列面积的50%。对于给定的阵列，只要阵列内的所有种子强度相等，参考等剂量线轮廓及其包围的面积与种子强度无关。
