治疗前全身免疫炎症指数和淋巴细胞与单核细胞比值作为口腔癌的预后因素：一项荟萃分析。
Pretreatment systemic immune-inflammation index and lymphocyte-to-monocyte ratio as prognostic factors in oral cavity cancer: A meta-analysis.
机构信息
Key Laboratory of Oral Diseases and Fujian Provincial Engineering Research Center of Oral Biomaterial and Stomatological Key Lab of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China.
Department of Medical Oncology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
出版信息
Medicine (Baltimore). 2024 Nov 1;103(44):e40182. doi: 10.1097/MD.0000000000040182.
BACKGROUND
The predictive implications of the pretreatment systemic immune-inflammation index (SII) and lymphocyte-to-monocyte ratio (LMR) in oral cavity cancer have been investigated extensively, however, the findings are conflicting.
METHODS
To assess the predictive importance of SII and LMR in patients with oral cavity cancer, a comprehensive Meta-analysis of the literature was conducted using the databases from PubMed, Embase, and the Cochrane Library. To determine the link between SII and LMR and overall survival (OS) and disease-free survival (DFS), hazard ratio (HR) and 95% confidence interval (CI) were retrieved.
RESULTS
The analysis comprised a total of 18 papers, covering 19 trials (SII = 5, LMR = 12, SII + prognostic nutritional index (PNI) = 2). According to pooled data, increased SII predicted poor OS (HR: 1.61, 95% CI: 1.38-1.87, P < .001) and DFS (HR: 1.90, 95% CI: 1.11-3.27, P = .02) while high LMR was linked with improved OS (HR: 0.64, 95% CI: 0.54-0.77, P < .001) and DFS (HR: 0.69, 95% CI: 0.61-0.79, P < .001). In addition, subgroup analysis indicated that high SII and low LMR negatively correlated with OS regardless of country, cutoff value, sample size, or types of Cox regression analysis.
CONCLUSIONS
High SII and low LMR may predict worse survival in patients with oral cavity cancer. SII and LMR may therefore represent effective indicators of prognosis in oral cavity cancer.
背景
术前全身免疫炎症指数（SII）和淋巴细胞与单核细胞比值（LMR）在口腔癌中的预测意义已被广泛研究，但结果存在争议。
方法
为了评估 SII 和 LMR 在口腔癌患者中的预测重要性，我们对 PubMed、Embase 和 Cochrane 图书馆的文献进行了全面的 Meta 分析。为了确定 SII 和 LMR 与总生存期（OS）和无病生存期（DFS）之间的关系，提取了风险比（HR）和 95%置信区间（CI）。
结果
该分析共包括 18 篇论文，涵盖 19 项试验（SII=5，LMR=12，SII+预后营养指数（PNI）=2）。根据汇总数据，升高的 SII 预测 OS 不良（HR：1.61，95%CI：1.38-1.87，P<0.001）和 DFS 不良（HR：1.90，95%CI：1.11-3.27，P=0.02），而高 LMR 与 OS 改善相关（HR：0.64，95%CI：0.54-0.77，P<0.001）和 DFS 改善（HR：0.69，95%CI：0.61-0.79，P<0.001）。此外，亚组分析表明，无论国家、截断值、样本量或 Cox 回归分析类型如何，高 SII 和低 LMR 均与 OS 呈负相关。
结论
高 SII 和低 LMR 可能预示着口腔癌患者的生存状况更差。因此，SII 和 LMR 可能是口腔癌预后的有效指标。
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