Zheng Huabo, Guo Tangmeng, Zhao Xiaofang, Wang Kun, Shan Shengshuai, Xie Songpu, Xu Yichen, Liu Chengyun, Lu Weilin
Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Cardiology, Fujian Medical University Union Hospital, Fuzhou, China.
Dig Dis. 2025;43(1):75-83. doi: 10.1159/000542180. Epub 2024 Nov 1.
Previous studies reported inconsistent results of the association between Helicobacter pylori infection and nonalcoholic fatty liver disease (NAFLD).
A cohort study of 2,063 adults without NAFLD at baseline, who participated in a repeated health checkup including a 13C-urea breath test and abdominal ultrasonography, was conducted to evaluate the link between H. pylori infection and NAFLD development.
During a mean follow-up period of 1.7 years, we did not find a significant association between H. pylori infection and NAFLD (hazard ratio = 1.10 (0.86, 1.40), p = 0.4689). We also found that higher age, body mass index (BMI), systolic blood pressure (systolic BP), diastolic blood pressure (diastolic BP), fasting blood glucose, triglycerides, total cholesterol, low-density lipoprotein cholesterol (LDL-C), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were risk factors, and high-density lipoprotein cholesterol (HDL-C) was a protective factor for NAFLD development.
H. pylori infection might not be positively related to NAFLD development.
先前的研究报告了幽门螺杆菌感染与非酒精性脂肪性肝病（NAFLD）之间关联的不一致结果。
对2063名基线时无NAFLD的成年人进行队列研究，这些人参加了包括13C尿素呼气试验和腹部超声检查在内的重复健康检查，以评估幽门螺杆菌感染与NAFLD发生之间的联系。
在平均1.7年的随访期内，我们未发现幽门螺杆菌感染与NAFLD之间存在显著关联（风险比=1.10（0.86，1.40），p=0.4689）。我们还发现，年龄较大、体重指数（BMI）、收缩压（收缩压）、舒张压（舒张压）、空腹血糖、甘油三酯、总胆固醇、低密度脂蛋白胆固醇（LDL-C）、丙氨酸氨基转移酶（ALT）和天冬氨酸氨基转移酶（AST）是NAFLD发生的危险因素，而高密度脂蛋白胆固醇（HDL-C）是NAFLD发生的保护因素。
幽门螺杆菌感染可能与NAFLD的发生无正相关。
