Aremu Oluwafemi Gbolahan, Asowata Osahon Jeffery, Danladi David Kadan, Okekunle Akinkunmi Paul, Akpa Onoja Matthew
Ascension Wisconsin Family Health Center, Milwaukee, WI, USA.
Department of Epidemiology and Medical Statistics, Faculty of Public Health, College of Medicine, University of Ibadan, Ibadan, Nigeria.
J Hum Hypertens. 2025 Feb;39(2):164-170. doi: 10.1038/s41371-024-00971-w. Epub 2024 Nov 4.
Hypertension is a major risk factor for cardiovascular events worldwide, and little is known about its association with sleep quality (SQ) among Africans. We evaluated the association of SQ with hypertension among adults in Ibadan, Nigeria. In Ibadan and its suburbs, we identified 3635 participants in the door-to-door Community-based Investigation of the Risk Factors for Cardiovascular Diseases (COMBAT-CVDs) study. SQ was self-reported, and SQ scores were classified by the tertile distribution in this sample as good (<9), moderate (10-18), and poor (≥19), and hypertension was defined as one of the following conditions: systolic blood pressure ≥140 mmHg or diastolic blood pressure ≥90 mmHg or prior diagnosis by a certified health professional or current use of blood pressure-lowering drugs. Using good SQ as a reference, logistic regression models were used to estimate the multivariable-adjusted odds ratio and 95% confidence interval (CI) for odds of hypertension by tertiles of SQ scores in a two-sided test at p < 0.05. In all, 1182 (32.5%) had poor SQ, 903 (24.8%) had hypertension, and the mean(±SD) age was 35.3 ± 15.2 years in this sample. The multivariable-adjusted odds of hypertension by tertiles of SQ scores (using good SQ as reference) were OR: 1.13 (95% CI: 0.92, 1.38) for moderate SQ, and OR: 1.29 (95% CI: 1.05, 1.59) for poor SQ; P for trend = 0.06 after adjusting for relevant covariates. Poor SQ is associated with higher odds of hypertension in this sample. The imperative of culturally sensitive interventions to improve SQ would be promising in managing poor sleep-associated hypertension burden in this population.
高血压是全球心血管事件的主要危险因素，而关于非洲人睡眠质量（SQ）与高血压之间的关联却知之甚少。我们评估了尼日利亚伊巴丹成年人中睡眠质量与高血压之间的关联。在伊巴丹及其郊区，我们在基于社区的心血管疾病危险因素入户调查（COMBAT-CVDs）研究中确定了3635名参与者。睡眠质量通过自我报告获得，在该样本中，睡眠质量得分按三分位数分布分为良好（<9分）、中等（10 - 18分）和较差（≥19分），高血压定义为以下情况之一：收缩压≥140 mmHg或舒张压≥90 mmHg，或经认证的健康专业人员先前诊断，或目前正在使用降压药物。以良好的睡眠质量为参照，采用逻辑回归模型在双侧检验中估计按睡眠质量得分三分位数划分的高血压患病几率的多变量调整比值比和95%置信区间（CI），检验水准为p < 0.05。在该样本中，共有1182人（32.5%）睡眠质量较差，903人（24.8%）患有高血压，平均（±标准差）年龄为35.3 ± 15.2岁。按睡眠质量得分三分位数划分的高血压多变量调整患病几率（以良好睡眠质量为参照），中等睡眠质量者的比值比为1.13（95% CI：0.92，1.38），较差睡眠质量者的比值比为1.29（95% CI：1.05，1.59）；在调整相关协变量后，趋势检验P值 = 0.06。在该样本中，较差的睡眠质量与较高的高血压患病几率相关。在该人群中，开展具有文化敏感性的干预措施以改善睡眠质量对于管理与睡眠不佳相关的高血压负担可能很有前景。
