Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China.
Hangzhou Normal University Xiaoshan Hospital, Zhejiang, China.
Sci Rep. 2024 Nov 4;14(1):26563. doi: 10.1038/s41598-024-77999-y.
To evaluate the knowledge, attitudes, and practices (KAP) of patients with age-related macular degeneration (AMD) regarding anti-VEGF treatment within a one-stop intravitreal injection service model. A cross-sectional study was conducted from July 1, 2023, to January 31, 2024, at the One-stop Intravitreal Injection Center at Tianjin Medical University Eye Hospital. Data were collected using a specially designed KAP questionnaire. The study successfully enrolled 493 participants. Of these, 214 (43.4%) were aged between 70 and 79 years, and 226 (45.8%) had been diagnosed with AMD for 1-3 years. The median knowledge, attitude, and practice scores were 6.00 [3.00, 8.00] (possible range: 0-9), 42.00 [37.00, 48.00] (possible range: 11-55), and 23.00 [18.00, 27.00] (possible range: 6-30), respectively. Multivariate logistic regression for practice showed that knowledge score (OR = 1.329, P < 0.001), attitude score (OR = 1.150, P < 0.001), aged 60-69 years (OR = 0.398, P = 0.022) were independently associated with proactive practice. Mediating effect significance showed that knowledge directly affected attitude (β = 0.625), knowledge (β = 0.398) and attitude (β = 0.503) directly affected practice (P < 0.001). Meanwhile, knowledge also indirectly affected practice through attitude (β = 0.315, P < 0.001). Regarding the factors impacting their selection of anti-VEGF treatment, 63.5% of patients emphasized the crucial role of its effectiveness. Additionally, over 40% of patients considered both family circumstances and insurance coverage to be highly significant in their decision-making process. This study found that patients with AMD exhibit suboptimal knowledge yet hold positive attitudes and engage actively in practices concerning anti-VEGF treatment within a one-stop intravitreal injection service model. It is recommended that healthcare providers enhance educational interventions at intravitreal injection centers to boost patient knowledge, which is likely to further improve attitudes and proactive management practices among AMD patients.
评估年龄相关性黄斑变性（AMD）患者在一站式玻璃体腔内注射服务模式下对抗 VEGF 治疗的知识、态度和实践（KAP）。这是一项 2023 年 7 月 1 日至 2024 年 1 月 31 日在天津医科大学眼科医院一站式玻璃体腔内注射中心进行的横断面研究。使用专门设计的 KAP 问卷收集数据。该研究成功纳入了 493 名参与者。其中，214 名（43.4%）年龄在 70-79 岁之间，226 名（45.8%）被诊断为 AMD 1-3 年。知识、态度和实践得分中位数分别为 6.00 [3.00, 8.00]（可能范围：0-9）、42.00 [37.00, 48.00]（可能范围：11-55）和 23.00 [18.00, 27.00]（可能范围：6-30）。实践的多变量逻辑回归显示，知识得分（OR=1.329，P<0.001）、态度得分（OR=1.150，P<0.001）、60-69 岁年龄（OR=0.398，P=0.022）与积极实践独立相关。中介效应显著表明，知识直接影响态度（β=0.625），知识（β=0.398）和态度（β=0.503）直接影响实践（P<0.001）。同时，知识也通过态度间接影响实践（β=0.315，P<0.001）。关于影响他们选择抗 VEGF 治疗的因素，63.5%的患者强调其疗效的关键作用。此外，超过 40%的患者认为家庭情况和保险覆盖范围在决策过程中非常重要。本研究发现，在一站式玻璃体腔内注射服务模式下，AMD 患者的知识水平欠佳，但对抗 VEGF 治疗的态度积极，积极参与实践。建议在玻璃体腔内注射中心加强教育干预，提高患者的知识水平，这可能会进一步提高 AMD 患者的态度和积极管理实践。
