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作为电休克治疗(ECT)、氯米帕明、阿米替林和苯乙肼治疗急性反应预测指标的地塞米松抑制试验(DST)

The DST as a predictor of acute response to treatment with ECT, chlorimipramine, amitriptyline, and phenelzine.

作者信息

Modai I, Rinsky H, Cygielman G

出版信息

J Clin Psychiatry. 1986 Mar;47(3):139-40.

PMID:3949722
Abstract

Plasma cortisol levels of 41 patients suffering from major depressive episodes were measured at 4 p.m. and 10 p.m. one day after administration of 1 mg dexamethasone at 10 p.m. Comparison of cortisol results to clinical improvement measured by the Beck Depression Inventory before and after 5 weeks of treatment with either ECT, chlorimipramine, amitriptyline, or phenelzine showed no difference between nonsuppressors and suppressors in relation to clinical improvement. Clinical prediction of the outcome of acute response to these treatments using an initial DST does not seem feasible.

摘要

在晚上10点给予1毫克地塞米松一天后的下午4点和晚上10点,测量了41名患有重度抑郁发作患者的血浆皮质醇水平。将皮质醇结果与使用电休克疗法(ECT)、氯米帕明、阿米替林或苯乙肼治疗5周前后通过贝克抑郁量表测量的临床改善情况进行比较,结果显示,非抑制者和抑制者在临床改善方面没有差异。使用初始地塞米松抑制试验(DST)对这些治疗的急性反应结果进行临床预测似乎不可行。

相似文献

1
The DST as a predictor of acute response to treatment with ECT, chlorimipramine, amitriptyline, and phenelzine.作为电休克治疗(ECT)、氯米帕明、阿米替林和苯乙肼治疗急性反应预测指标的地塞米松抑制试验(DST)
J Clin Psychiatry. 1986 Mar;47(3):139-40.
2
Depression after minor closed head injury: role of dexamethasone suppression test and antidepressants.轻度闭合性颅脑损伤后的抑郁:地塞米松抑制试验及抗抑郁药的作用
J Clin Psychiatry. 1985 Aug;46(8):335-8.
3
Pretreatment dexamethasone suppression test as a predictor of response to phenelzine.
J Clin Psychiatry. 1987 Dec;48(12):480-2.
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[Dexamethasone test: suppressors and non-suppressors, what's the difference?].
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Retrospective evaluation of the dexamethasone suppression test as a predictor of response to electroconvulsive therapy in patients with comorbid major depressive disorder and posttraumatic stress disorder.回顾性评估地塞米松抑制试验作为伴有共病的重度抑郁症和创伤后应激障碍患者对电抽搐治疗反应的预测因子。
J ECT. 2010 Sep;26(3):213-7. doi: 10.1097/YCT.0b013e3181c30481.
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J Clin Psychopharmacol. 1988 Dec;8(6):421-5.
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The dexamethasone suppression test and ECT outcome: a six-month follow-up.地塞米松抑制试验与电休克治疗结果:六个月随访
Biol Psychiatry. 1983 Jan;18(1):21-7.
8
Clinical and DST response to bilateral sinusoidal but not to unilateral brief-pulse ECT.临床及药物敏感性试验对双侧正弦波电休克治疗有反应,但对单侧短脉冲电休克治疗无反应。
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Changes in serial dexamethasone suppression tests among unipolar depressive receiving electroconvulsive treatment.接受电休克治疗的单相抑郁症患者连续地塞米松抑制试验的变化
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DST has no predictive ability for acute response to ECT.地塞米松抑制试验对电休克治疗的急性反应没有预测能力。
J Clin Psychiatry. 1986 Dec;47(12):612.