Saran A S
J Clin Psychiatry. 1985 Aug;46(8):335-8.
The results of dexamethasone suppression test (DST) and the effectiveness of amitriptyline and phenelzine in treating depression with melancholia after minor closed head injury in 10 patients were compared to those in 12 control patients with primary depression and melancholia. Prevalence of abnormal DST results was higher in the control group (91%) than in the closed head injury group (10%). Results of the DST corresponded with clinical improvement. Amitriptyline produced significant and consistent improvement in all control patients at the end of 4 weeks of treatment. No patient in the closed head injury group showed significant improvement with amitriptyline. The closed head injury patients were treated with phenelzine after a 3- to 7-day washout period. No statistical improvement after 4 weeks of treatment with phenelzine was seen in any of these patients. The DST may be useful as an adjunct to the diagnostic and monitoring process in primary depression with melancholia. Depression after minor closed head injury did not correlate with the DST. Amitriptyline and phenelzine have limited use (if any) in depression with melancholia after minor closed head injury.
将10例轻度闭合性颅脑损伤后伴有忧郁症的抑郁症患者的地塞米松抑制试验（DST）结果以及阿米替林和苯乙肼治疗该病的有效性，与12例原发性抑郁症伴忧郁症的对照患者进行了比较。DST异常结果的发生率在对照组（91%）高于闭合性颅脑损伤组（10%）。DST结果与临床改善情况相符。阿米替林在治疗4周结束时使所有对照患者均有显著且持续的改善。闭合性颅脑损伤组中没有患者使用阿米替林后有显著改善。在经过3至7天的洗脱期后，闭合性颅脑损伤患者接受了苯乙肼治疗。这些患者在接受苯乙肼治疗4周后均未出现统计学上的改善。DST可能有助于原发性抑郁症伴忧郁症的诊断和监测过程。轻度闭合性颅脑损伤后的抑郁症与DST无关。阿米替林和苯乙肼在轻度闭合性颅脑损伤后伴有忧郁症的抑郁症中的应用有限（若有应用的话）。
