Berrettini W H
J Clin Psychiatry. 1986 Mar;47(3):147.
A case of serious carbamazepine toxicity as a result of concomitant erythromycin therapy is presented. Carbamazepine competes with erythromycin for metabolism by hepatic microsomal enzymes, resulting in decreased clearance of carbamazepine. Carbamazepine drug interactions will become increasingly important to psychiatrists as this anticonvulsant becomes more widely used to treat affective disorders.
本文报告了一例因同时使用红霉素治疗而导致严重卡马西平中毒的病例。卡马西平与红霉素竞争肝脏微粒体酶代谢，导致卡马西平清除率降低。随着这种抗惊厥药物越来越广泛地用于治疗情感障碍，卡马西平的药物相互作用对精神科医生来说将变得越来越重要。
