完整核小体中高度乙酰化的H4组蛋白与特异性抗体的结合情况。
Availability of hyperacetylated H4 histone in intact nucleosomes to specific antibodies.
作者信息
Pfeffer U, Ferrari N, Vidali G
出版信息
J Biol Chem. 1986 Feb 25;261(6):2496-8.
PMID:3949730
Abstract
Specific antibodies against the tetra-acetylated form of H4 histone have been elicited in the rabbit. They do not cross-react with the non-, mono-, and di-acetylated forms of the histone molecule but a slight cross-reactivity with the tri-acetylated form of H4 histone is observed. Our studies also show that hyperacetylated H4 histones are recognized by the antibodies in intact nucleosomes.
摘要
针对H4组蛋白四乙酰化形式的特异性抗体已在兔子体内产生。它们与组蛋白分子的非乙酰化、单乙酰化和二乙酰化形式不发生交叉反应，但观察到与H4组蛋白的三乙酰化形式有轻微的交叉反应。我们的研究还表明，高乙酰化的H4组蛋白在完整的核小体中能被抗体识别。
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