Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
School of Clinical Medicine, Weifang Medical University, Weifang, China.
J Alzheimers Dis. 2024 Nov;102(1):77-88. doi: 10.1177/13872877241284216. Epub 2024 Oct 17.
The correlation between Alzheimer's disease (AD) and the glucose-triglyceride (TyG) index remains undetermined.
This study aimed to investigate the relationship between the TyG index and AD, as well as the relationship between the TyG index and cerebrospinal fluid (CSF) AD biomarkers and cognition.
Six hundred twenty-eight non-dementia participants were included. The TyG index, pathological markers, and cognitive measures were studied using multiple linear regression. Also calculated using a multivariate Cox regression model were the hazard ratio (HR) and its 95% confidence interval (CI). Ten thousand bootstrap iterative causal mediation analyses were performed to investigate the potential mediating effect of AD pathology on cognition.
The TyG index was linked to CSF AD biomarkers (β= 0.880; β= -0.674; β= -0.884; β= 1.764; β= 1.554; β= -0.210) and cognitive measurements (β= 0.570; β= 0.535; β= -0.789). Mediation analysis revealed that the TyG index may influence cognition via CSF AD biomarkers, including Aβ, tau, and pTau. Furthermore, each 1-unit increase in TyG index was associated with a 29.5% reduction in the risk of incident AD.
A delayed rate of cognitive decline and a reduced risk of AD were found to be correlated with higher levels of the TyG index, but this does not mean increasing TyG index levels is beneficial for health. Through AD pathology, the TyG index may influence AD and cognitive changes.
阿尔茨海默病（AD）与葡萄糖-甘油三酯（TyG）指数之间的相关性尚未确定。
本研究旨在探讨 TyG 指数与 AD 之间的关系，以及 TyG 指数与脑脊液（CSF）AD 生物标志物和认知之间的关系。
纳入了 628 名非痴呆参与者。使用多元线性回归研究了 TyG 指数、病理标志物和认知测量值。还使用多变量 Cox 回归模型计算了风险比（HR）及其 95%置信区间（CI）。进行了 10000 次 bootstrap 迭代因果中介分析，以研究 AD 病理学对认知的潜在中介作用。
TyG 指数与 CSF AD 生物标志物（β=0.880；β=-0.674；β=-0.884；β=1.764；β=1.554；β=-0.210）和认知测量值（β=0.570；β=0.535；β=-0.789）相关。中介分析表明，TyG 指数可能通过 CSF AD 生物标志物（包括 Aβ、tau 和 pTau）影响认知。此外，TyG 指数每增加 1 个单位，AD 事件的风险就会降低 29.5%。
较高的 TyG 指数与认知衰退速度减慢和 AD 风险降低相关，但这并不意味着增加 TyG 指数水平对健康有益。通过 AD 病理学，TyG 指数可能影响 AD 和认知变化。
