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Messing up with the regulator: A rational AI-driven drug design strategy to disrupt miRNA-target interactions.

作者信息

Leitão Ana Lúcia, Enguita Francisco J

机构信息

Departmento de Química, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, Campus da Caparica, 2829-516 Caparica, Portugal.

Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal.

出版信息

Mol Ther Nucleic Acids. 2024 Oct 19;35(4):102353. doi: 10.1016/j.omtn.2024.102353. eCollection 2024 Dec 10.

DOI:10.1016/j.omtn.2024.102353
PMID:39497811
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11532966/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00bc/11532966/a06f76b80704/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00bc/11532966/a06f76b80704/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00bc/11532966/a06f76b80704/gr1.jpg

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本文引用的文献

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SMTRI: A deep learning-based web service for predicting small molecules that target miRNA-mRNA interactions.SMTRI:一种基于深度学习的网络服务,用于预测靶向miRNA- mRNA相互作用的小分子。
Mol Ther Nucleic Acids. 2024 Aug 15;35(3):102303. doi: 10.1016/j.omtn.2024.102303. eCollection 2024 Sep 10.
2
Trials and Tribulations of MicroRNA Therapeutics.miRNA 治疗的困境与挑战
Int J Mol Sci. 2024 Jan 25;25(3):1469. doi: 10.3390/ijms25031469.
3
Programming inactive RNA-binding small molecules into bioactive degraders.将无活性的 RNA 结合小分子编程为生物活性降解物。
Nature. 2023 Jun;618(7963):169-179. doi: 10.1038/s41586-023-06091-8. Epub 2023 May 24.
4
Emerging concepts of miRNA therapeutics: from cells to clinic.miRNA 治疗学的新观念:从细胞到临床。
Trends Genet. 2022 Jun;38(6):613-626. doi: 10.1016/j.tig.2022.02.006. Epub 2022 Mar 15.
5
A Structural View of miRNA Biogenesis and Function.微小RNA生物合成与功能的结构视角
Noncoding RNA. 2022 Jan 18;8(1):10. doi: 10.3390/ncrna8010010.
6
A Loop-Based and AGO-Incorporated Virtual Screening Model Targeting AGO-Mediated miRNA-mRNA Interactions for Drug Discovery to Rescue Bone Phenotype in Genetically Modified Mice.一种基于环和包含AGO的虚拟筛选模型,靶向AGO介导的miRNA-mRNA相互作用用于药物发现,以挽救基因修饰小鼠的骨骼表型。
Adv Sci (Weinh). 2020 May 28;7(13):1903451. doi: 10.1002/advs.201903451. eCollection 2020 Jul.
7
Inforna 2.0: A Platform for the Sequence-Based Design of Small Molecules Targeting Structured RNAs.Inforna 2.0:一个用于基于序列设计靶向结构化RNA的小分子的平台。
ACS Chem Biol. 2016 Jun 17;11(6):1720-8. doi: 10.1021/acschembio.6b00001. Epub 2016 Apr 20.
8
HCV infection and miravirsen.
N Engl J Med. 2013 Aug 29;369(9):877-8. doi: 10.1056/NEJMc1307787.