Okeke Kizito I, Ahamefule Chukwuemeka Samson, Nnabuife Obianuju O, Orabueze Ibuchukwu N, Iroegbu Christian U, Egbe Kingsley A, Ike Anthony C
Department of Microbiology, Faculty of Biological Sciences, University of Nigeria, Nsukka 410001 Enugu State, Nigeria.
Department of Medical Microbiology, University of Nigeria Teaching Hospital Enugu, Enugu State, Nigeria.
Curr Res Microb Sci. 2024 Oct 16;7:100293. doi: 10.1016/j.crmicr.2024.100293. eCollection 2024.
Notably, severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS) and coronavirus disease 2019 (COVID-19) have all had significant negative impact on global health and economy. COVID-19 alone, has resulted to millions of deaths with new cases and mortality still being reported in its various waves. The development and use of vaccines have not stopped the transmission of SARS coronavirus 2 (SARS-CoV-2), the etiological agent of COVID-19, even among vaccinated individuals. The use of vaccines and curative drugs should be supplemented with adoption of simple hygiene preventive measures in the fight against the spread of the virus, especially for healthcare workers. Several virucidal topical antiseptics, such as povidone-iodine (PVP-I), citrox, cyclodextrins among others, have been demonstrated to be efficacious in the inactivation of SARS-CoV-2 and other coronaviruses in both and studies. The strategic application of these virucidal formulations could provide the additional impetus needed to effectively control the spread of the virus. We have here presented a simple dimension towards curtailing the dissemination of COVID-19, and other coronaviruses, through the application of effective oral, nasal and eye antiseptics among patients and medical personnel. We have further discussed the mechanism of action of some of these commonly available virucidal solutions while also highlighting some essential controversies in their use.
值得注意的是，严重急性呼吸综合征（SARS）、中东呼吸综合征（MERS）和2019冠状病毒病（COVID-19）都对全球健康和经济产生了重大负面影响。仅COVID-19就已导致数百万人死亡，其不同传播浪潮中仍有新病例和死亡报告。疫苗的研发和使用并未阻止严重急性呼吸综合征冠状病毒2（SARS-CoV-2，COVID-19的病原体）的传播，即使在接种疫苗的个体中也是如此。在抗击病毒传播的斗争中，疫苗和治疗药物的使用应辅以采取简单的卫生预防措施，尤其是对医护人员而言。几种具有杀病毒作用的局部消毒剂，如聚维酮碘（PVP-I）、西曲溴铵、环糊精等，在体外和体内研究中均已证明对SARS-CoV-2和其他冠状病毒的灭活有效。这些杀病毒制剂的战略应用可为有效控制病毒传播提供额外动力。我们在此提出了一个简单的方法，即通过在患者和医务人员中应用有效的口服、鼻腔和眼部消毒剂来减少COVID-19和其他冠状病毒的传播。我们还进一步讨论了其中一些常用杀病毒溶液的作用机制，同时也强调了其使用中的一些重要争议。
