Ansher S S, Jakoby W B
J Biol Chem. 1986 Mar 25;261(9):3996-4001.
N-Methylation of amines has been ascribed to enzymes listed as amine N-methyltransferase, indolethylamine N-methyltransferase, and arylamine N-methyltransferase. All of these activities are accomplished by each of two related enzymes present in rabbit liver. The two N-methyltransferases have a very broad and overlapping specificity for primary and secondary amines. Both have a molecular mass of 30,000 daltons and react with an antibody formed to one of them, but have different isoelectric points.
胺的N-甲基化作用归因于被列为胺N-甲基转移酶、吲哚乙胺N-甲基转移酶和芳胺N-甲基转移酶的酶。所有这些活性都由兔肝脏中存在的两种相关酶中的每一种来完成。这两种N-甲基转移酶对伯胺和仲胺具有非常广泛且重叠的特异性。两者的分子量均为30,000道尔顿，并且都能与针对其中一种形成的抗体发生反应，但具有不同的等电点。
