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用于数字健康研究的以患者为中心的病例 vignettes 的统计优化。

Statistical refinement of patient-centered case vignettes for digital health research.

作者信息

Kopka Marvin, Feufel Markus A

机构信息

Division of Ergonomics, Department of Psychology and Ergonomics (IPA), Technische Universität Berlin, Berlin, Germany.

出版信息

Front Digit Health. 2024 Oct 21;6:1411924. doi: 10.3389/fdgth.2024.1411924. eCollection 2024.

DOI:10.3389/fdgth.2024.1411924
PMID:39498100
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11532084/
Abstract

Digital health research often relies on case vignettes (descriptions of fictitious or real patients) to navigate ethical and practical challenges. Despite their utility, the quality and lack of standardization of these vignettes has often been criticized, especially in studies on symptom-assessment applications (SAAs) and self-triage decision-making. To address this, our paper introduces a method to refine an existing set of vignettes, drawing on principles from classical test theory. First, we removed any vignette with an item difficulty of zero and an item-total correlation below zero. Second, we stratified the remaining vignettes to reflect the natural base rates of symptoms that SAAs are typically approached with, selecting those vignettes with the highest item-total correlation in each quota. Although this two-step procedure reduced the size of the original vignette set by 40%, comparing self-triage performance on the reduced and the original vignette sets, we found a strong correlation ( = 0.747 to  = 0.997,  < .001). This indicates that using our refinement method helps identifying vignettes with high predictive power of an agent's self-triage performance while simultaneously increasing cost-efficiency of vignette-based evaluation studies. This might ultimately lead to higher research quality and more reliable results.

摘要

数字健康研究通常依靠病例 vignettes(虚构或真实患者的描述)来应对伦理和实际挑战。尽管它们很有用,但这些 vignettes 的质量和缺乏标准化常常受到批评,尤其是在症状评估应用(SAA)和自我分诊决策的研究中。为了解决这个问题,我们的论文引入了一种方法,利用经典测试理论的原则来完善现有的一组 vignettes。首先,我们删除了任何项目难度为零且项目总分相关性低于零的 vignette。其次,我们对其余的 vignettes 进行分层,以反映 SAA 通常处理的症状的自然基础率,在每个配额中选择项目总分相关性最高的那些 vignettes。尽管这个两步程序使原始 vignette 集的大小减少了 40%,但比较减少后的和原始 vignette 集上的自我分诊性能,我们发现了很强的相关性(= 0.747 至 = 0.997,< 0.001)。这表明使用我们的完善方法有助于识别对个体自我分诊性能具有高预测力的 vignettes,同时提高基于 vignette 的评估研究的成本效益。这最终可能导致更高的研究质量和更可靠的结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29b9/11532084/7fac65ddb967/fdgth-06-1411924-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29b9/11532084/7fac65ddb967/fdgth-06-1411924-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29b9/11532084/7fac65ddb967/fdgth-06-1411924-g001.jpg

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The diagnostic and triage accuracy of the GPT-3 artificial intelligence model: an observational study.GPT-3 人工智能模型的诊断和分诊准确性:一项观察性研究。
Lancet Digit Health. 2024 Aug;6(8):e555-e561. doi: 10.1016/S2589-7500(24)00097-9.
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How suitable are clinical vignettes for the evaluation of symptom checker apps? A test theoretical perspective.临床案例对症状检查应用程序评估的适用性如何?一个测试理论视角。
Digit Health. 2023 Aug 21;9:20552076231194929. doi: 10.1177/20552076231194929. eCollection 2023 Jan-Dec.
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The Triage Capability of Laypersons: Retrospective Exploratory Analysis.非专业人员的分诊能力:回顾性探索性分析
JMIR Form Res. 2022 Oct 12;6(10):e38977. doi: 10.2196/38977.
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Triage Accuracy of Symptom Checker Apps: 5-Year Follow-up Evaluation.症状检查器应用程序的分诊准确性:5 年随访评估。
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What is the suitability of clinical vignettes in benchmarking the performance of online symptom checkers? An audit study.临床病例在基准测试在线症状检查器的性能方面的适用性如何?一项审计研究。
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