Prida Eva, Pérez-Lois Raquel, Jácome-Ferrer Pablo, Muñoz-Moreno Diego, Brea-García Beatriz, Villalón María, Pena-Leon Verónica, Vázquez-Cobela Rocío, Aguilera Concepción M, Conde-Aranda Javier, Costas Javier, Estany-Gestal Ana, Quiñones Mar, Leis Rosaura, Seoane Luisa María, Al-Massadi Omar
Translational Endocrinology Group, Endocrinology Section, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)/Complexo Hospitalario Universitario de Santiago (SERGAS), Travesía da Choupana s/n, 15706 Santiago de Compostela, Galicia, Spain.
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Av Monforte de Lemos3-5, 28029 Madrid, Spain.
iScience. 2024 Oct 9;27(11):111120. doi: 10.1016/j.isci.2024.111120. eCollection 2024 Nov 15.
Previous studies determined that Pyk2 is involved in several diseases in which the symptomatology presents alterations in energy balance. However, its role in obesity is poorly understood. To evaluate the metabolic role of the Pyk2 gene () in children and adolescents with obesity we measured its mRNA expression levels in peripheral blood mononuclear cells. For that we performed a cross-sectional study involving 130 Caucasian subjects that was divided into two groups according to BMI. Data showed increased mRNA expression in children and adolescents with obesity. Interestingly, a positive correlation has been found between the levels of with weight, BMI, BMI score, fat mass, waist circumference, waist to height ratio, diastolic blood pressure, and leptin. In addition, it is indicated that high levels of gene expression might be a predictor of obesity development. This work provides important insights into the previously undescribed role of Pyk2 in obesity.
先前的研究确定，Pyk2参与了几种疾病，这些疾病的症状表现为能量平衡改变。然而，其在肥胖症中的作用却鲜为人知。为了评估Pyk2基因（）在肥胖儿童和青少年中的代谢作用，我们测量了其在外周血单核细胞中的mRNA表达水平。为此，我们进行了一项横断面研究，涉及130名白种人受试者，根据BMI将其分为两组。数据显示，肥胖儿童和青少年中mRNA表达增加。有趣的是，已发现与体重、BMI、BMI评分、脂肪量、腰围、腰高比、舒张压和瘦素水平之间存在正相关。此外，研究表明，Pyk2基因的高表达水平可能是肥胖发展的一个预测指标。这项工作为Pyk2在肥胖症中以前未被描述的作用提供了重要见解。
