Wei Junhan, Cheng Ziyun, Kong Deying, Lin Wenman, Hess Robert F, Zhou Jiawei, Reynaud Alexandre
National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
State Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Front Psychol. 2024 Oct 21;15:1494964. doi: 10.3389/fpsyg.2024.1494964. eCollection 2024.
The study aimed to explore potential discrepancies in contrast sensitivity in the ON and OFF visual pathways among individuals with amblyopia compared to controls.
Eleven adult amblyopes (26.2 ± 4.4 [SD] years old) and 10 controls (24.6 ± 0.8 years old) with normal or corrected to normal visual acuity (logMAR VA ≤ 0) participated in this study. Using the quick contrast sensitivity function (qCSF) algorithm, we measured balanced CSF which would stimulate the ON and OFF pathways unselectively, and CSFs for increments and decrements that would selectively stimulate the ON and OFF visual pathways. Contrast sensitivity and area under log contrast sensitivity function were extracted for statistical analysis.
For the balanced CSF, we found significant interocular differences in sensitivity and area under log contrast sensitivity function in both amblyopes [(1,10) = 74.992, < 0.001] and controls [(1,9) = 35.6, < 0.001], while such differences were more pronounced in amblyopes than in controls. For increment and decrement CSFs, we found that the increment sensitivity ( = 0.038) and area under log contrast sensitivity function ( = 0.001) were significantly lower than the decrement in the amblyopic eye. Such differences between increment and decrement CSFs were not observed in the fellow eye of the amblyopes or in the controls.
There is a subtle difference in the contrast sensitivity of the amblyopic eye when exposed to stimulation in the ON and OFF pathways.
本研究旨在探讨与对照组相比，弱视个体的开视觉通路和关视觉通路中对比敏感度的潜在差异。
11名成年弱视患者（年龄26.2±4.4[标准差]岁）和10名视力正常或矫正后正常（logMAR视力≤0）的对照组（年龄24.6±0.8岁）参与了本研究。使用快速对比敏感度函数（qCSF）算法，我们测量了能无选择性地刺激开通路和关通路的平衡对比敏感度函数（CSF），以及能选择性地刺激开视觉通路和关视觉通路的增量和减量CSF。提取对比敏感度和对数对比敏感度函数下的面积进行统计分析。
对于平衡CSF，我们发现弱视患者[(1,10)=74.992，P<0.001]和对照组[(1,9)=35.6，P<0.001]在敏感度和对数对比敏感度函数下的面积方面均存在显著的双眼差异，而这种差异在弱视患者中比在对照组中更明显。对于增量和减量CSF，我们发现弱视眼的增量敏感度（P=0.038）和对数对比敏感度函数下的面积（P=0.001）显著低于减量敏感度。在弱视患者的对侧眼或对照组中未观察到增量和减量CSF之间的这种差异。
当弱视眼在开通路和关通路中受到刺激时，其对比敏感度存在细微差异。
