Feng Xiaoying, Jia Ping, Zhang Dingding
College of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Department of Neurosurgery Nursing, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Front Pharmacol. 2024 Jul 25;15:1435133. doi: 10.3389/fphar.2024.1435133. eCollection 2024.
Depression is a chronic mental disorder characterized by persistent low mood and loss of interest. Treatments for depression are varied but may not be sufficient cure. Drug-based treatment regimens have drawbacks such as slow onset of action, low bioavailability, and drug side effects. Nanocarrier Drug Delivery Systems (NDDS) has received increasing attention for brain drug delivery since it assists the drug through the blood-brain barrier and improves bioavailability, which may be beneficial for treating depression. Due to the particle size and physicochemical properties of nanocarriers, it presents a promise to improve the stability and solubility of antidepressants, thereby enhancing the drug concentration. Moreover, ligand-modified nanocarriers can be taken as a target direct medicines release system and reduce drug side effects. The purpose of the present review is to provide an up-to-date understanding of the Nanocarrier drug delivery system and relevant antidepressants in different routes of ingestion, to lay a foundation for the treatment of patients with depression.
抑郁症是一种慢性精神障碍，其特征为持续的情绪低落和兴趣丧失。抑郁症的治疗方法多种多样，但可能无法完全治愈。基于药物的治疗方案存在起效缓慢、生物利用度低和药物副作用等缺点。纳米载体药物递送系统（NDDS）因其能协助药物通过血脑屏障并提高生物利用度，在脑内药物递送方面受到越来越多的关注，这可能对治疗抑郁症有益。由于纳米载体的粒径和物理化学性质，它有望提高抗抑郁药的稳定性和溶解度，从而提高药物浓度。此外，配体修饰的纳米载体可作为靶向直接释药系统，减少药物副作用。本综述的目的是提供对纳米载体药物递送系统及不同给药途径中相关抗抑郁药的最新认识，为抑郁症患者的治疗奠定基础。
