Harquail Centre for Neuromodulation.
Division of Neurosurgery, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada.
Curr Opin Neurol. 2024 Dec 1;37(6):682-692. doi: 10.1097/WCO.0000000000001314. Epub 2024 Oct 4.
Brain tumor treatment presents challenges for patients and clinicians, with prognosis for many of the most common brain tumors being poor. Focused ultrasound (FUS) can be deployed in several ways to circumvent these challenges, including the need to penetrate the blood-brain barrier and spare healthy brain tissue. This article reviews current FUS applications within neuro-oncology, emphasizing ongoing or recently completed clinical trials.
Most clinical interest in FUS for neuro-oncology remains focused on exploring BBB disruption to enhance the delivery of standard-of-care therapeutics. More recently, the application of FUS for radiosensitization, liquid biopsy, and sonodynamic therapy is garnering increased clinical attention to assist in tumor ablation, early detection, and phenotypic diagnosis. Preclinical studies show encouraging data for the immunomodulatory effects of FUS, but these findings have yet to be tested clinically.
FUS is a burgeoning area of neuro-oncology research. Data from several forthcoming large clinical trials should help clarify its role in neuro-oncology care.
脑肿瘤的治疗对患者和临床医生提出了挑战，许多最常见的脑肿瘤的预后都很差。聚焦超声（FUS）可以通过多种方式来应对这些挑战，包括需要穿透血脑屏障并保护健康的脑组织。本文综述了神经肿瘤学中 FUS 的现有应用，重点介绍了正在进行或最近完成的临床试验。
神经肿瘤学中 FUS 的临床应用仍然集中在探索 BBB 破坏以增强标准治疗药物的递送。最近，FUS 在放射增敏、液体活检和声动力学治疗中的应用引起了人们对辅助肿瘤消融、早期检测和表型诊断的更多关注。临床前研究为 FUS 的免疫调节作用提供了令人鼓舞的数据，但这些发现尚未在临床上得到验证。
FUS 是神经肿瘤学研究的一个新兴领域。几项即将进行的大型临床试验的数据应有助于阐明其在神经肿瘤学治疗中的作用。
