Howden C W, Fletcher C D, Farish E, Reid J L
J Clin Pharmacol. 1986 Feb;26(2):97-9. doi: 10.1002/j.1552-4604.1986.tb02913.x.
Serum lipoproteins were monitored in 24 healthy subjects receiving either ranitidine or cimetidine for four weeks. Ranitidine produced a significant (P less than .05) reduction in high-density lipoprotein (HDL)-cholesterol in both men and women. Cimetidine caused a nonsignificant increase in HDL-cholesterol and a reduction in LDL-cholesterol that was significant (P less than .05) only in women. As these drugs had opposite effects on HDL-cholesterol levels, the mechanism of action is unlikely to be medicated by H2-receptor blockade.
对24名接受雷尼替丁或西咪替丁治疗四周的健康受试者的血清脂蛋白进行了监测。雷尼替丁使男性和女性的高密度脂蛋白（HDL）胆固醇均显著降低（P<0.05）。西咪替丁使HDL胆固醇有不显著的升高，而低密度脂蛋白胆固醇降低，且仅在女性中显著（P<0.05）。由于这些药物对HDL胆固醇水平有相反的作用，其作用机制不太可能是通过H2受体阻断介导的。
