Shigenaga Y, Okamoto T, Nishimori T, Suemune S, Nasution I D, Chen I C, Tsuru K, Yoshida A, Tabuchi K, Hosoi M
J Comp Neurol. 1986 Feb 1;244(1):1-18. doi: 10.1002/cne.902440102.
Transganglionic transport of horseradish peroxidase (HRP) was used to study the patterns of termination of somatic afferent fibers innervating oral and facial structures within the principal nucleus (Vp), nucleus oralis (Vo), and nucleus interpolaris (Vi). The primary trigeminal afferent fibers that innervate the oral cavity supplied by the pterygopalatine, superior alveolar, lingual, buccal, and inferior alveolar branches, as well as the facial skin supplied by the frontal, corneal, zygomatic, infraorbital, auriculotemporal, mylohyoid, and mental branches, were traced in this experiment. The results show that trigeminal afferent nerves that innervate the oral cavity project mainly to the principal nucleus, the rostrodorsomedial part (Vo.r) and dorsomedial division (Vo.dm) of pars oralis, and the dorsomedial region of pars interpolaris, while an extensive overlap of projections is found in the Vo.r, Vo.dm, and rostral Vi. The central processes of fibers innervating the anterior face (i.e., mental, infraorbital, and frontal nerves) terminate in the ventral division of principalis (Vpv), caudal region pars oralis (Vo.c), and ventrolateral Vi, with the largest numbers of terminals being found in the Vpv and Vi. In contrast, the central projection patterns of the corneal, zygomatic, mylohyoid, and auriculotemporal afferents are different from those of other afferent nerves examined, and present a discrete projection to the trigeminal sensory nuclear complex (TSNC). The corneal, mylohyoid, and auriculotemporal afferents mainly project to the restricted regions of principalis and caudal Vi, while zygomatic afferent nerve fibers project to the caudal third of pars interpolaris. The typical somatotopic organization with the face of the mouth open inverted is represented in the rostrocaudal midlevels of the Vpv and caudal pars interpolaris. The Vpd receives topographical projection from primary afferent nerves that innervate the oral structure only, while this projection was organized in a complicated manner. The relationship between the functional segregation and the cytoarchitectonic differentiation of the TSNC is discussed, particularly with respect to this somatotopic organization, combined with the characteristics of projecting cells in the TSNC.
利用辣根过氧化物酶（HRP）的跨节运输来研究支配口腔和面部结构的躯体传入纤维在主核（Vp）、口核（Vo）和极间核（Vi）内的终止模式。在本实验中追踪了由翼腭、上牙槽、舌、颊和下牙槽分支供应的支配口腔的三叉神经初级传入纤维，以及由额、角膜、颧、眶下、耳颞、下颌舌骨和颏分支供应的面部皮肤的传入纤维。结果表明，支配口腔的三叉神经传入神经主要投射到主核、口部的 rostrodorsomedial 部分（Vo.r）和背内侧部（Vo.dm）以及极间部的背内侧区域，而在 Vo.r、Vo.dm 和 Vi 的头端发现了广泛的投射重叠。支配前脸（即颏、眶下和额神经）的纤维的中枢突终止于主核的腹侧部（Vpv）、口部的尾侧区域（Vo.c）和腹外侧 Vi，其中在 Vpv 和 Vi 中发现的终末数量最多。相比之下，角膜、颧、下颌舌骨和耳颞传入纤维的中枢投射模式与其他检查的传入神经不同，并向三叉神经感觉核复合体（TSNC）呈现离散投射。角膜、下颌舌骨和耳颞传入纤维主要投射到主核和尾侧 Vi 的受限区域，而颧传入神经纤维投射到极间部的尾侧三分之一。在 Vpv 和尾侧极间部的前后中平面中呈现出典型的躯体定位组织，即口张开时的面部呈倒置状态。Vpd 仅从支配口腔结构的初级传入神经接受地形投射，而这种投射是以复杂的方式组织的。讨论了 TSNC 的功能分离与细胞构筑分化之间的关系，特别是关于这种躯体定位组织，并结合了 TSNC 中投射细胞的特征。
