酿酒酵母交配型位点的基因转换

Gene conversion of the mating-type locus in Saccharomyces cerevisiae.

作者信息

Klar A J, Fogel S, Lusnak K

出版信息

Genetics. 1979 Jul;92(3):777-82. doi: 10.1093/genetics/92.3.777.

DOI:10.1093/genetics/92.3.777

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1214036/

Abstract

Tetrad analysis of MATa/MAT alpha diploids of Saccharomyces cerevisiae generally yields 2 MATa:2MAT alpha meiotic products. About 1 to 1.8% of the tetrads yield aberrant segregations for this marker. Described here are experiments that determine whether the aberrant meiotic segregations at the mating-type locus are ascribable to gene conversions or to MAT switches, that is, to mating-type interconversions. Diploid strains incapable of switching MATa to MAT alpha, or the converse, nevertheless display changes of MATa to MAT alpha, or the reverse. These events must be attributed to gene conversion. Further, we suggest that MATa and MAT alpha alleles may represent nonhomologous sequences of DNA since they fail to display postmeiotic segregations.

摘要

对酿酒酵母MATa/MATα二倍体进行四分体分析，通常会产生2个MATa:2个MATα的减数分裂产物。对于这个标记，约1%至1.8%的四分体产生异常分离。本文描述的实验旨在确定交配型位点的异常减数分裂分离是归因于基因转换还是MAT转换，即交配型的相互转换。不能将MATa转换为MATα或反之的二倍体菌株，仍然会出现MATa到MATα或相反的变化。这些事件必定归因于基因转换。此外，我们认为MATa和MATα等位基因可能代表非同源DNA序列，因为它们未表现出减数分裂后分离。

相似文献

1

Gene conversion of the mating-type locus in Saccharomyces cerevisiae.酿酒酵母交配型位点的基因转换

Genetics. 1979 Jul;92(3):777-82. doi: 10.1093/genetics/92.3.777.

2

Switching of a mating-type a mutant allele in budding yeast Saccharomyces cerevisiae.芽殖酵母酿酒酵母中一个交配型a突变等位基因的转换。

Genetics. 1979 Jul;92(3):759-76. doi: 10.1093/genetics/92.3.759.

3

Homothallic mating type switching generates lethal chromosome breaks in rad52 strains of Saccharomyces cerevisiae.同宗配合型转换在酿酒酵母的rad52菌株中产生致死性染色体断裂。

Mol Cell Biol. 1981 Jun;1(6):522-34. doi: 10.1128/mcb.1.6.522-534.1981.

4

A mutation that permits the expression of normally silent copies of mating-type information in Saccharomyces cerevisiae.一种能使酿酒酵母中通常沉默的交配型信息拷贝得以表达的突变。

Genetics. 1979 Sep;93(1):13-35. doi: 10.1093/genetics/93.1.13.

5

Mutations preventing transpositions of yeast mating type alleles.阻止酵母交配型等位基因转座的突变。

Proc Natl Acad Sci U S A. 1980 May;77(5):2824-8. doi: 10.1073/pnas.77.5.2824.

6

Double-strand breaks can initiate meiotic recombination in S. cerevisiae.双链断裂可在酿酒酵母中引发减数分裂重组。

Cell. 1986 Aug 29;46(5):733-40. doi: 10.1016/0092-8674(86)90349-1.

7

Heteroduplex formation and mismatch repair of the "stuck" mutation during mating-type switching in Saccharomyces cerevisiae.酿酒酵母交配型转换过程中“滞留”突变的异源双链体形成与错配修复。

Mol Cell Biol. 1991 Oct;11(10):5372-80. doi: 10.1128/mcb.11.10.5372-5380.1991.

8

Meiotic exchange within and between chromosomes requires a common Rec function in Saccharomyces cerevisiae.酿酒酵母中染色体内部和之间的减数分裂交换需要一种共同的Rec功能。

Mol Cell Biol. 1985 Dec;5(12):3532-44. doi: 10.1128/mcb.5.12.3532-3544.1985.

9

Evidence for a physical interaction between the transposed and the substituted sequences during mating type gene transposition in yeast.酵母中交配型基因转座过程中转座序列与替代序列之间存在物理相互作用的证据。

Cell. 1980 Nov;22(1 Pt 1):291-8. doi: 10.1016/0092-8674(80)90176-2.

10

A suppressor of mating-type locus mutations in Saccharomyces cerevisiae: evidence for and identification of cryptic mating-type loci.酿酒酵母交配型基因座突变的抑制因子：隐蔽交配型基因座的证据及鉴定

Genetics. 1979 Dec;93(4):877-901. doi: 10.1093/genetics/93.4.877.

引用本文的文献

1

SIRT1-FOXO3a regulate cocaine actions in the nucleus accumbens.沉默调节蛋白1-叉头框蛋白O3a调控伏隔核中的可卡因作用。

J Neurosci. 2015 Feb 18;35(7):3100-11. doi: 10.1523/JNEUROSCI.4012-14.2015.

2

Regulation of nuclear positioning and dynamics of the silent mating type loci by the yeast Ku70/Ku80 complex.酵母Ku70/Ku80复合体对沉默交配型基因座的核定位及动态变化的调控

Mol Cell Biol. 2009 Feb;29(3):835-48. doi: 10.1128/MCB.01009-08. Epub 2008 Dec 1.

3

Yeast autonomously replicating sequence binding factor is involved in nucleotide excision repair.酵母自主复制序列结合因子参与核苷酸切除修复。

Genes Dev. 1999 Dec 1;13(23):3052-8. doi: 10.1101/gad.13.23.3052.

4

Structure and function of a mating-type gene from the homothallic species Neurospora africana.来自同宗配合物种非洲脉孢菌的一个交配型基因的结构与功能。

Mol Gen Genet. 1994 Aug 15;244(4):401-9. doi: 10.1007/BF00286692.

5

Genetical and molecular analyses of qa-2 transformants in Neurospora crassa.粗糙脉孢菌qa-2转化体的遗传学和分子分析。

Genetics. 1986 Jul;113(3):569-87. doi: 10.1093/genetics/113.3.569.

本文引用的文献

1

A DELETION IN YEAST AND ITS BEARING ON THE STRUCTURE OF THE MATING TYPE LOCUS.酵母中的一个缺失及其与交配型基因座结构的关系。

Genetics. 1963 Dec;48(12):1727-9. doi: 10.1093/genetics/48.12.1727.

2

Postmeiotic segregation in Saccharomyces.酿酒酵母中的减数分裂后分离

Mol Gen Genet. 1971;111(3):297-9. doi: 10.1007/BF00433113.

3

The genetic system controlling homothallism in Saccharomyces yeasts.控制酿酒酵母同宗配合的遗传系统。

Genetics. 1974 Aug;77(4):639-50. doi: 10.1093/genetics/77.4.639.

4

Mapping of the homothallic genes, HM alpha and HMa, in Saccharomyces yeasts.酿酒酵母中同宗配合基因HMα和HMa的定位

Genetics. 1976 Nov;84(3):437-51. doi: 10.1093/genetics/84.3.437.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。