Gnanapandithan Karthik, Stemboroski Lauren, Johnston Abbey, Ghali Maged P
Division of Hospital Internal Medicine Mayo Clinic Jacksonville Florida USA.
Division of Gastroenterology and Hepatology University of Florida Jacksonville Florida USA.
JGH Open. 2024 Nov 4;8(11):e70049. doi: 10.1002/jgh3.70049. eCollection 2024 Nov.
HCV is marked by genetic diversity that impacts disease progression and outcome. Using the NHANES data from 266 HCV-infected adults (2011-2020), this study infers that genotype 1a is the most prevalent (60.2%). Genotype 3 was associated with higher transaminase levels, though not statistically significant. These findings suggest a more aggressive phenotype for genotype 3. Despite pan-genotypic treatment guidelines, this underscores the importance of continued HCV genotype surveillance and consideration for genotype-specific treatment and monitoring strategies.
丙型肝炎病毒（HCV）具有基因多样性，这会影响疾病的进展和结局。本研究利用2011年至2020年266名HCV感染成年人的美国国家健康与营养检查调查（NHANES）数据推断，1a基因型最为普遍（60.2%）。3基因型与较高的转氨酶水平相关，尽管无统计学意义。这些发现表明3基因型具有更强的侵袭性表型。尽管有泛基因型治疗指南，但这凸显了持续进行HCV基因型监测以及考虑采用基因型特异性治疗和监测策略的重要性。
