Khan Shahida Aziz, Zughaibi Torki Al, Khan Sarah A
King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
Int J Health Sci (Qassim). 2024 Nov-Dec;18(6):3-9.
The alarming increase in vitamin D deficiency (VDD) has been shown to result in compounded risks of major health problems globally. As sickle cell disease (SCD) children are already health compromised, the co-morbidities escalate early in life, demanding an early detection, to minimize the adverse effects. This study determined vitamin D levels in children with SCD without a crisis to check for probable associations with inflammation and infections if any.
SCD children aged 5-16 years, in a steady state, were enrolled in the study after taking necessary consent and ethical clearance. Hb, serum calcium, vitamin D, and high-sensitivity C-reactive protein (hsCRP) levels were analyzed.
VDD was seen in most of the children with SCD irrespective of gender and age. Males aged 5-10 years showed significance ( = 0.0375) with vitamin D and white blood cell (WBC) ( = 0.0015) but males aged 11-16-year age group exhibited a very strong-positive correlation with vitamin D (r = 0.9862) and a very strong-negative correlation with Hb (r = -0.9819) and hsCRP (r = -0.9907). Among females, the 11-16-year age group patients exhibited a significant association with vitamin D ( = 0.0487), Ca ( = 0.0118), Hb ( = 0.0007), and hsCRP ( = 0.0001) levels. Correlation "r" values in this age group show a strong-negative correlation with WBC levels (r = -0.6525) as well as hsCRP (r = - 0.6550).
The increased deficiency of vitamin D in SCD children should be addressed at early ages of life, to reduce the occurrence and severity of associated comorbidities.
全球范围内，维生素D缺乏（VDD）现象激增，这已被证明会导致严重的健康问题风险叠加。由于镰状细胞病（SCD）患儿本身健康状况不佳，其合并症在幼年时就会加剧，因此需要早期检测，以尽量减少不良影响。本研究测定了无危象的SCD患儿的维生素D水平，以检查是否存在与炎症和感染的可能关联（若有）。
年龄在5至16岁、处于稳定状态的SCD患儿在获得必要的同意和伦理批准后纳入研究。分析血红蛋白（Hb）、血清钙、维生素D和高敏C反应蛋白（hsCRP）水平。
大多数SCD患儿均存在VDD，与性别和年龄无关。5至10岁的男性患儿维生素D与白细胞（WBC）之间存在显著相关性（P = 0.0375）（P = 0.0015），但11至16岁年龄组的男性患儿维生素D呈极强正相关（r = 0.9862），与Hb呈极强负相关（r = -0.9819），与hsCRP呈极强负相关（r = -0.9907）。在女性患儿中，11至16岁年龄组的患者维生素D与钙（P = 0.0118）、Hb（P = 0.0007）和hsCRP（P = 0.0001）水平之间存在显著关联。该年龄组的相关性“r”值显示与WBC水平呈强负相关（r = -0.6525），与hsCRP也呈强负相关（r = -0.6550）。
应在SCD患儿幼年时解决维生素D缺乏加剧的问题，以减少相关合并症的发生和严重程度。
