Al-Dhubaibi Mohammed Saleh
Department of Dermatology, College of Medicine, Qassim University, Saudi Arabia.
Int J Health Sci (Qassim). 2018 Jan-Feb;12(1):33-9.
Deficiency of Vitamin D is a widespread problem. Vitamin D could have important immune modulatory effects in psoriasis.
Aimed to review and endeavored to establish the relationship, if any, between deficiency of Vitamin D and psoriasis.
Leading studies that examined the relationship between deficiency of Vitamin D and psoriasis were reviewed from July2016 to October 2016. An electronic published work search was performed using PubMed, Ovid MEDLINE, Google Scholar, and Saudi Digital Library.
A total of 2132 eligible articles were identified by the electronic search. The titles and abstracts of 954 articles fulfilled the criteria of midline search. 20 articles were included after application of inclusion standards and full-text review. These 20 studies included 2046 psoriatic patients with or without arthritis and 6508 healthy controls. 14 studies show a positive correlation between Vitamin D deficiency and psoriasis. These 14 studies included 1249 psoriatic patients with or without arthritis and 680 healthy controls. Remaining six studies, including 797 psoriatic patients with or without arthritis and 5828 healthy controls do not depict a positive correlation between the two variables under study.
There exists a correlation of psoriasis with deficiency of Vitamin D. However, there is a need for larger scale case-control studies to assess how far Vitamin D deficiency plays a role in psoriasis.
维生素D缺乏是一个普遍存在的问题。维生素D可能在银屑病中具有重要的免疫调节作用。
旨在回顾并努力确定维生素D缺乏与银屑病之间是否存在关系。
回顾了2016年7月至2016年10月期间研究维生素D缺乏与银屑病之间关系的主要研究。使用PubMed、Ovid MEDLINE、谷歌学术和沙特数字图书馆进行了电子文献检索。
通过电子检索共识别出2132篇符合条件的文章。954篇文章的标题和摘要符合中线检索标准。在应用纳入标准并进行全文审查后，纳入了20篇文章。这20项研究包括2046例有或无关节炎的银屑病患者和6508例健康对照。14项研究表明维生素D缺乏与银屑病之间存在正相关。这14项研究包括1249例有或无关节炎的银屑病患者和680例健康对照。其余6项研究，包括797例有或无关节炎的银屑病患者和5828例健康对照，未显示所研究的两个变量之间存在正相关。
银屑病与维生素D缺乏之间存在相关性。然而，需要进行更大规模的病例对照研究来评估维生素D缺乏在银屑病中起多大作用。
