通过检测支气管灌洗液中的t(11;18)(q21;q21)诊断出的一例肺黏膜相关淋巴组织淋巴瘤。
A case of pulmonary mucosa-associated lymphoid tissue lymphoma diagnosed by detecting t(11;18)(q21;q21) in bronchial lavage fluid.
作者信息
Nakamura Yusuke, Takemasa Akihiro, Ohoka Yuki, Tsukada Nobuhiko, Tsukada Azusa, Nakazato Yoshimasa, Mitani Kinuko, Toyoda Akihiko, Shimizu Yasuo, Niho Seiji
机构信息
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi, 321-0293, Japan.
Respiratory endoscopy center, Dokkyo Medical University Hospital, 880 Kitakobayashi, Mibu, Tochigi, 321-0293, Japan.
出版信息
Respir Med Case Rep. 2024 Oct 17;52:102133. doi: 10.1016/j.rmcr.2024.102133. eCollection 2024.
A 76-year-old woman was diagnosed with mucosa-associated lymphoid tissue (MALT) lymphoma by upper gastrointestinal endoscopy. She underwent further investigation for concomitant bilateral pleural effusions and right pulmonary consolidation. MALT lymphoma with the t(11; 18)(q21; q21) translocation and were detected in pleural fluid. Lymphoma was not histopathologically diagnosed by lung biopsies, but the same translocation was identified in bronchial lavage. MALT lymphoma is often difficult to diagnose by bronchoscopy because of only mild dysplasia. However, present report on using chromosomal translocation analysis from bronchial lavage indicates that such testing may serve as a useful diagnostic adjunct in MALT lymphoma with lung involvement.
一名76岁女性经上消化道内镜检查被诊断为黏膜相关淋巴组织（MALT）淋巴瘤。她因合并双侧胸腔积液和右肺实变接受了进一步检查。在胸腔积液中检测到伴有t(11; 18)(q21; q21)易位的MALT淋巴瘤。肺活检在组织病理学上未诊断出淋巴瘤，但在支气管灌洗中发现了相同的易位。由于仅存在轻度发育异常，MALT淋巴瘤通过支气管镜检查往往难以诊断。然而，本报告关于利用支气管灌洗进行染色体易位分析表明，这种检测可能作为MALT淋巴瘤肺受累的一种有用的辅助诊断方法。
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